O
O. Wolf Lindwasser
Researcher at National Institutes of Health
Publications - 10
Citations - 8635
O. Wolf Lindwasser is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Cancer & Clinical trial. The author has an hindex of 8, co-authored 9 publications receiving 7669 citations.
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Journal ArticleDOI
Imaging intracellular fluorescent proteins at nanometer resolution.
Eric Betzig,George H. Patterson,Rachid Sougrat,O. Wolf Lindwasser,Scott G. Olenych,Juan S. Bonifacino,Michael W. Davidson,Jennifer Lippincott-Schwartz,Harald F. Hess +8 more
TL;DR: This work introduced a method for optically imaging intracellular proteins at nanometer spatial resolution and used this method to image specific target proteins in thin sections of lysosomes and mitochondria and in fixed whole cells to image retroviral protein Gag at the plasma membrane.
Journal ArticleDOI
Downregulation of CD4 by Human Immunodeficiency Virus Type 1 Nef Is Dependent on Clathrin and Involves Direct Interaction of Nef with the AP2 Clathrin Adaptor
TL;DR: A model in which HIV-1 Nef downregulates CD4 by promoting its accelerated endocytosis by a clathrin-associated, plasma membrane-localized AP2 complex is supported.
Journal ArticleDOI
ctDNA applications and integration in colorectal cancer: an NCI Colon and Rectal-Anal Task Forces whitepaper.
Arvind Dasari,Van K. Morris,Carmen J. Allegra,Chloe E. Atreya,Al B. Benson,Patrick McKay Boland,Ki Y. Chung,Mehmet Sitki Copur,Ryan B. Corcoran,Dustin A. Deming,Andrea Dwyer,Maximilian Diehn,Cathy Eng,Thomas J. George,Marc J. Gollub,Rachel Anne Goodwin,Stanley R. Hamilton,Jaclyn F. Hechtman,Howard S. Hochster,Theodore S. Hong,Federico Innocenti,Atif Iqbal,Samuel A. Jacobs,Hagen F. Kennecke,James J. Lee,Christopher H. Lieu,Heinz-Josef Lenz,O. Wolf Lindwasser,C. Montagut,Bruno C. Odisio,Fang-Shu Ou,Laura S. Porter,Kanwal Pratap Singh Raghav,Deborah Schrag,Aaron Scott,Qian Shi,John H. Strickler,Alan P. Venook,Rona Yaeger,Greg Yothers,Y. Nancy You,Jason A. Zell,Scott Kopetz +42 more
TL;DR: The panel focused on four key areas in which ctDNA has the potential to change clinical practice, including the detection of minimal residual disease, the management of patients with rectal cancer, monitoring responses to therapy, and tracking clonal dynamics in response to targeted therapies and other systemic treatments.
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Mechanisms of CD4 downregulation by the Nef and Vpu proteins of primate immunodeficiency viruses.
TL;DR: Primate immunodeficiency viruses have evolved at least two distinct mechanisms, mediated by the Nef and Vpu viral proteins, to "downregulate" CD4 in the host cells, which are essential for efficient virus replication and disease progression.
Journal ArticleDOI
A Diacidic Motif in Human Immunodeficiency Virus Type 1 Nef Is a Novel Determinant of Binding to AP-2
O. Wolf Lindwasser,William J. Smith,Rittik Chaudhuri,Peter C. Yang,James H. Hurley,Juan S. Bonifacino +5 more
TL;DR: The notion that AP-2 is the key clathrin adaptor for the downregulation of CD4 by Nef is supported, and a previously unrecognized diversity among dileucine sorting signals is revealed.