O
Oana M. Enache
Researcher at Broad Institute
Publications - 14
Citations - 3176
Oana M. Enache is an academic researcher from Broad Institute. The author has contributed to research in topics: Breast cancer & Gene. The author has an hindex of 8, co-authored 12 publications receiving 1647 citations. Previous affiliations of Oana M. Enache include University of California & Lawrence Berkeley National Laboratory.
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Journal ArticleDOI
A Next Generation Connectivity Map: L1000 Platform and the First 1,000,000 Profiles.
Aravind Subramanian,Rajiv Narayan,Steven M. Corsello,Steven M. Corsello,David Peck,Ted Natoli,Xiaodong Lu,Joshua Gould,John F. Davis,Andrew A. Tubelli,Jacob K. Asiedu,David L. Lahr,Jodi E. Hirschman,Zihan Liu,Melanie Donahue,Bina Julian,Mariya Khan,David Wadden,Ian Smith,Daniel D. Lam,Arthur Liberzon,Courtney Toder,Mukta Bagul,Marek Orzechowski,Oana M. Enache,Federica Piccioni,Sarah A. Johnson,Nicholas J. Lyons,Alice H. Berger,Alice H. Berger,Alykhan F. Shamji,Angela N. Brooks,Angela N. Brooks,Anita Vrcic,Corey Flynn,Jacqueline Rosains,David Y. Takeda,David Y. Takeda,Roger Hu,Desiree Davison,Justin Lamb,Kristin Ardlie,Larson Hogstrom,Peyton Greenside,Nathanael S. Gray,Nathanael S. Gray,Paul A. Clemons,Serena J. Silver,Xiaoyun Wu,Wen-Ning Zhao,Wen-Ning Zhao,Willis Read-Button,Xiaohua Wu,Stephen J. Haggarty,Stephen J. Haggarty,Lucienne Ronco,Jesse S. Boehm,Stuart L. Schreiber,Stuart L. Schreiber,Stuart L. Schreiber,John G. Doench,Joshua A. Bittker,David E. Root,Bang Wong,Todd R. Golub +64 more
TL;DR: The expanded CMap is reported, made possible by a new, low-cost, high-throughput reduced representation expression profiling method that is shown to be highly reproducible, comparable to RNA sequencing, and suitable for computational inference of the expression levels of 81% of non-measured transcripts.
Posted ContentDOI
A Next Generation Connectivity Map: L1000 Platform And The First 1,000,000 Profiles
Aravind Subramanian,Rajiv Narayan,Steven M. Corsello,David Peck,Ted Natoli,Xiaodong Lu,Joshua Gould,John F. Davis,Andrew A. Tubelli,Jacob K. Asiedu,David L. Lahr,Jodi E. Hirschman,Zihan Liu,Melanie Donahue,Bina Julian,Mariya Khan,David Wadden,Ian Smith,Daniel D. Lam,Arthur Liberzon,Courtney Toder,Mukta Bagul,Marek Orzechowski,Oana M. Enache,Federica Piccioni,Alice H. Berger,Alykhan F. Shamji,Angela N. Brooks,Anita Vrcic,Corey Flynn,Jacqueline Rosains,David Y. Takeda,Desiree Davison,Justin Lamb,Kristin Ardlie,Larson Hogstrom,Nathanael S. Gray,Paul A. Clemons,Serena J. Silver,Xiaoyun Wu,Wen-Ning Zhao,Willis Read-Button,Xiaohua Wu,Stephen J. Haggarty,Lucienne Ronco,Jesse S. Boehm,Stuart L. Schreiber,John G. Doench,Joshua A. Bittker,David E. Root,Bang Wong,Todd R. Golub +51 more
TL;DR: A new, low-cost, high throughput reduced representation expression profiling method, L1000, is shown to be highly reproducible, comparable to RNA sequencing, and suitable for computational inference of the expression levels of 81% of non-measured transcripts.
Journal ArticleDOI
Modeling precision treatment of breast cancer
Anneleen Daemen,Anneleen Daemen,Anneleen Daemen,Obi L. Griffith,Obi L. Griffith,Obi L. Griffith,Laura M. Heiser,Laura M. Heiser,Nicholas J. Wang,Nicholas J. Wang,Oana M. Enache,Zachary Sanborn,Francois Pepin,Steffen Durinck,James E. Korkola,James E. Korkola,Malachi Griffith,Joe S Hur,Nam Huh,Jongsuk Chung,Leslie Cope,Mary Jo Fackler,Christopher B. Umbricht,Saraswati Sukumar,Pankaj Seth,Vikas P. Sukhatme,Lakshmi Jakkula,Yiling Lu,Gordon B. Mills,Raymond J. Cho,Eric A. Collisson,Eric A. Collisson,Laura J. van't Veer,Paul T. Spellman,Paul T. Spellman,Joe W. Gray,Joe W. Gray +36 more
TL;DR: It is suggested that matching patients to treatments based on transcriptional subtype will improve response rates, and inclusion of additional features from other profiling data types may provide additional benefit.
Journal ArticleDOI
Cas9 activates the p53 pathway and selects for p53-inactivating mutations.
Oana M. Enache,Veronica Rendo,Mai Abdusamad,Daniel D. Lam,Desiree Davison,Sangita Pal,Naomi Currimjee,Julian M. Hess,Sasha Pantel,Anwesha Nag,Aaron R. Thorner,John G. Doench,Francisca Vazquez,Rameen Beroukhim,Rameen Beroukhim,Todd R. Golub,Uri Ben-David,Uri Ben-David +17 more
TL;DR: Genetic and transcriptional consequences of Cas9 expression induces DNA damage and activates the p53 pathway, and it can lead to the selection of cells with p53-inactivating mutations, and Cas9 is less active in wild-type TP53 cell lines than in TP53- mutant cell lines.
Journal ArticleDOI
Noncanonical open reading frames encode functional proteins essential for cancer cell survival
John R. Prensner,John R. Prensner,John R. Prensner,Oana M. Enache,Victor Luria,Karsten Krug,Karl R. Clauser,Joshua M. Dempster,Amir Karger,Li Wang,Karolina Stumbraite,Vickie M. Wang,Ginevra Botta,Nicholas J. Lyons,Amy Goodale,Zohra Kalani,Briana Fritchman,Adam Brown,Douglas Alan,Thomas M Green,Xiaoping Yang,Jacob D. Jaffe,Jennifer Roth,Federica Piccioni,Federica Piccioni,Marc W. Kirschner,Zhe Ji,David E. Root,Todd R. Golub,Todd R. Golub,Todd R. Golub +30 more
TL;DR: This article showed that non-canonical open reading frames (ORFs) can express biologically active proteins that are potential therapeutic targets, such as glycine-rich extracellular protein-1 (GREP1), which is highly expressed in breast cancer.