O
Obukowicz Mark G
Researcher at G. D. Searle & Company
Publications - 18
Citations - 710
Obukowicz Mark G is an academic researcher from G. D. Searle & Company. The author has contributed to research in topics: Arachidonic acid & Polyunsaturated fatty acid. The author has an hindex of 9, co-authored 18 publications receiving 699 citations. Previous affiliations of Obukowicz Mark G include Monsanto & Guangzhou Institutes of Biomedicine and Health.
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Patent
Substituted benzopyran derivatives for the treatment of inflammation
Jeffery S. Carter,Obukowicz Mark G,Balekudru Devadas,John J. Talley,David L. Brown,Matthew J. Graneto,Stephen R. Bertenshaw,Donald J. Rogier,Srinivasan Nagarajan,Cathleen E. Hanau,Susan J. Hartmann,Cindy L. Ludwig,Suzanne Metz +12 more
TL;DR: A class of benzopyran derivatives for use in treating cyclooxygenase-2 mediated disorders was described in this article, where compounds of particular interest are defined by Formula (I'), wherein X, A?1, A2, A3, A4?, R, R', R?1 and R2? are as described in the specification.
Journal ArticleDOI
Highly Unsaturated (n-3) Fatty Acids, but Not α-Linolenic, Conjugated Linoleic or γ-Linolenic Acids, Reduce Tumorigenesis in ApcMin/+ Mice
TL;DR: The results suggest that SDA and EPA attenuate tumorigenesis in this model and that this effect may be related in part to alterations in prostaglandin biosynthesis.
Patent
Substituted benzopyran analogs for the treatment of inflammation
Jeffery S. Carter,Obukowicz Mark G,Balekudru Devadas,John J. Talley,David L. Brown,Matthew J. Graneto,Stephen R. Bertenshaw,Donald J. Rogier,Srinivasan Nagarajan,Cathleen E. Hanau,Susan J. Hartmann,Cindy L. Ludwig,Suzanne Metz,Korte Donald E +13 more
TL;DR: In this article, a class of benzopyrans, benzothiopyrans and dihydroquinolines, dihydronaphthalenes, and analogs thereof, are described for use in treating cyclooxygenase-2 mediated disorders.
Journal ArticleDOI
Novel, Selective Δ6 or Δ5 Fatty Acid Desaturase Inhibitors as Antiinflammatory Agents in Mice
Obukowicz Mark G,Dean Welsch,William J. Salsgiver,Cynthia L. Martin-Berger,Kevin Chinn,Kevin L. Duffin,Amiram Raz,Philip Needleman +7 more
TL;DR: In this paper, a Delta6 desaturase inhibitor, SC-26196, had pharmacokinetic and pharmacodynamic profiles in mice that allowed for the evaluation of the pharmacological effects of chronic inhibition of desaturases activity.
Journal ArticleDOI
Electrospray/tandem mass spectrometry for quantitative analysis of lipid remodeling in essential fatty acid deficient mice.
TL;DR: The overall body of data presented illustrates the implementation of electrospray/tandem mass spectrometry as a method for facile and direct quantification of changes in lipid species during lipid metabolic studies.