O
Olafur T. Magnusson
Researcher at deCODE genetics
Publications - 57
Citations - 10032
Olafur T. Magnusson is an academic researcher from deCODE genetics. The author has contributed to research in topics: Population & Medicine. The author has an hindex of 31, co-authored 46 publications receiving 8433 citations. Previous affiliations of Olafur T. Magnusson include University of Iceland & Amgen.
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Journal ArticleDOI
Rate of de novo mutations and the importance of father’s age to disease risk
Augustine Kong,Michael L. Frigge,Gisli Masson,Søren Besenbacher,Søren Besenbacher,Patrick Sulem,Gisli Magnusson,Sigurjon A. Gudjonsson,Asgeir Sigurdsson,Aslaug Jonasdottir,Adalbjorg Jonasdottir,Wendy S.W. Wong,Gunnar Th. Sigurdsson,G. Bragi Walters,Stacy Steinberg,Hannes Helgason,Gudmar Thorleifsson,Daniel F. Gudbjartsson,Agnar Helgason,Agnar Helgason,Olafur T. Magnusson,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Kari Stefansson,Kari Stefansson +24 more
TL;DR: A study of genome-wide mutation rates by sequencing the entire genomes of 78 Icelandic parent–offspring trios at high coverage shows that the diversity in mutation rate of single nucleotide polymorphisms is dominated by the age of the father at conception of the child.
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A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline
Thorlakur Jonsson,Jasvinder K. Atwal,Stacy Steinberg,Jon Snaedal,Palmi V. Jonsson,Sigurbjorn Bjornsson,Hreinn Stefansson,Patrick Sulem,Daniel F. Gudbjartsson,Janice A. Maloney,Kwame Hoyte,Amy Gustafson,Yichin Liu,Yanmei Lu,Tushar Bhangale,Robert R. Graham,Johanna Huttenlocher,Gyda Bjornsdottir,Ole A. Andreassen,Erik G. Jönsson,Aarno Palotie,Timothy W. Behrens,Olafur T. Magnusson,Augustine Kong,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Ryan J. Watts,Kari Stefansson,Kari Stefansson +28 more
TL;DR: The strong protective effect of the A673T substitution against Alzheimer’s disease provides proof of principle for the hypothesis that reducing the β-cleavage of APP may protect against the disease.
Journal ArticleDOI
Spread of SARS-CoV-2 in the Icelandic Population.
Daniel F. Gudbjartsson,Agnar Helgason,Hakon Jonsson,Olafur T. Magnusson,Páll Melsted,Gudmundur L. Norddahl,Jona Saemundsdottir,Asgeir Sigurdsson,Patrick Sulem,Arna B Agustsdottir,Berglind Eiriksdottir,Run Fridriksdottir,Elisabet E Gardarsdottir,Gudmundur Georgsson,Olafia S Gretarsdottir,Kjartan R Gudmundsson,Thora R Gunnarsdottir,Arnaldur Gylfason,Hilma Holm,Brynjar O. Jensson,Aslaug Jonasdottir,Frosti Jonsson,Kamilla S Josefsdottir,Thordur Kristjansson,Droplaug N Magnusdottir,Louise le Roux,Gudrun Sigmundsdottir,Gardar Sveinbjornsson,Kristin E Sveinsdottir,Maney Sveinsdottir,Emil A Thorarensen,Bjarni Thorbjornsson,Arthur Löve,Gisli Masson,Ingileif Jonsdottir,Alma D. Möller,Thorolfur Gudnason,Karl G. Kristinsson,Unnur Thorsteinsdottir,Kari Stefansson +39 more
TL;DR: In a population-based study in Iceland, children under 10 years of age and females had a lower incidence of SARS-CoV-2 infection than adolescents or adults and males and the proportion of infected participants identified through population screening remained stable for the 20-day duration of screening.
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Humoral Immune Response to SARS-CoV-2 in Iceland.
Daniel F. Gudbjartsson,Gudmundur L. Norddahl,Páll Melsted,Kristbjorg Gunnarsdottir,Hilma Holm,Elias Eythorsson,Asgeir O. Arnthorsson,Dadi Helgason,Kristbjorg Bjarnadottir,Ragnar Freyr Ingvarsson,Brynja Thorsteinsdottir,Steinunn Kristjánsdóttir,Kolbrun Birgisdottir,Anna M. Kristinsdottir,Martin I. Sigurdsson,Gudny A. Arnadottir,Erna V. Ivarsdottir,Margret B. Andresdottir,Frosti Jonsson,Arna B Agustsdottir,Jonas Berglund,Berglind Eiriksdottir,Run Fridriksdottir,Elisabet E Gardarsdottir,Magnus Gottfredsson,Olafia S Gretarsdottir,Steinunn Gudmundsdottir,Kjartan R Gudmundsson,Thora R Gunnarsdottir,Arnaldur Gylfason,Agnar Helgason,Brynjar O. Jensson,Aslaug Jonasdottir,Hakon Jonsson,Thordur Kristjansson,Karl G. Kristinsson,Droplaug N Magnusdottir,Olafur T. Magnusson,Lovisa Bjork Olafsdottir,Solvi Rognvaldsson,Louise le Roux,Gudrun Sigmundsdottir,Asgeir Sigurdsson,Gardar Sveinbjornsson,Kristin E Sveinsdottir,Maney Sveinsdottir,Emil A Thorarensen,Bjarni Thorbjornsson,Marianna Thordardottir,Jona Saemundsdottir,S Hjortur Kristjansson,Kamilla S Josefsdottir,Gisli Masson,Gudmundur Georgsson,Mar Kristjansson,Alma D. Möller,Runolfur Palsson,Thorolfur Gudnason,Unnur Thorsteinsdottir,Ingileif Jonsdottir,Patrick Sulem,Kari Stefansson +61 more
TL;DR: The authors' results indicate that antiviral antibodies against SARS-CoV-2 did not decline within 4 months after diagnosis, and antiviral antibody titers assayed by two pan-Ig assays remained on a plateau for the remainder of the study.
Journal ArticleDOI
Clonal hematopoiesis, with and without candidate driver mutations, is common in the elderly.
Florian Zink,Simon N. Stacey,Gudmundur L. Norddahl,Michael L. Frigge,Olafur T. Magnusson,Ingileif Jonsdottir,Ingileif Jonsdottir,Thorgeir E. Thorgeirsson,Asgeir Sigurdsson,Sigurjon A. Gudjonsson,Julius Gudmundsson,Jon G. Jonasson,Laufey Tryggvadottir,Thorvaldur Jonsson,Agnar Helgason,Arnaldur Gylfason,Patrick Sulem,Thorunn Rafnar,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Daniel F. Gudbjartsson,Daniel F. Gudbjartsson,Gisli Masson,Augustine Kong,Kari Stefansson,Kari Stefansson +25 more
TL;DR: It is found that CH is very common in the elderly, trending toward inevitability, and somatic mutations in TET2, DNMT3A, ASXL1, and PPM1D are associated with CH at high significance, however, known CD mutations were evident in only a fraction of CH cases.