scispace - formally typeset
Search or ask a question
Author

Olaniyi Kehinde

Bio: Olaniyi Kehinde is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Adipose tissue & 3T3-L1 Cells. The author has an hindex of 7, co-authored 8 publications receiving 4821 citations.

Papers
More filters
Journal ArticleDOI
01 May 1975-Cell
TL;DR: Lipogenic and lipolytic hormones and drugs affect the rate of synthesis and accumulation of triglyceride by 3T3-L1 cells, but in contrast to bromodeoxyuridine, these modulating agents do not seem to affect the proportion of cells which undergoes the adipose conversion.

1,374 citations

Journal ArticleDOI
TL;DR: It will be shown here that large amounts of cultured epithelium can be generated from a small piece of epidermis in a short time.
Abstract: Owing to several recent developments, the cultivability of epidermal keratinocytes, particularly those of the human, has been greatly improved. Under the conditions used, single cultured cells generate stratified colonies that ultimately fuse and form an epithelium that is reasonable approximation of the epidermis. It will be shown here that large amounts of cultured epithelium can be generated from a small piece of epidermis in a short time. We wish to bring to the attention of surgeons and cell biologists the possibility of using culture-grown epithelium derived from the same individual to restore defects in the epidermis.

1,204 citations

Journal ArticleDOI
01 Mar 1974-Cell
TL;DR: Two clonal sublines are isolated from the established mouse fibroblast line 3T3 that accumulate large amounts of triglyceride fat when the cells are in the resting state and are reduced by lipolytic agents.

931 citations

Journal ArticleDOI
TL;DR: The cells from a small piece of epidermis can be grown into a large number of cultured epithelia, which were grafted onto full-thickness burn wounds in two patients, and survived for the period of observation.

901 citations


Cited by
More filters
Journal ArticleDOI
TL;DR: The primary goals of the treatment of wounds are rapid wound closure and a functional and aesthetically satisfactory scar.
Abstract: The primary function of the skin is to serve as a protective barrier against the environment. Loss of the integrity of large portions of the skin as a result of injury or illness may lead to major disability or even death. Every year in the United States more than 1.25 million people have burns1 and 6.5 million have chronic skin ulcers caused by pressure, venous stasis, or diabetes mellitus.2 The primary goals of the treatment of wounds are rapid wound closure and a functional and aesthetically satisfactory scar. Recent advances in cellular and molecular biology have greatly expanded our understanding . . .

5,462 citations

Journal ArticleDOI
TL;DR: It is demonstrated that cell shape regulates commitment of human mesenchymal stem cells to adipocyte or osteoblast fate and mechanical cues experienced in developmental and adult contexts, embodied by cell shape, cytoskeletal tension, and RhoA signaling, are integral to the commitment of stem cell fate.

3,995 citations

Journal ArticleDOI
30 Dec 1994-Cell
TL;DR: The results suggest that the physiologic role of PPAR gamma 2 is to regulate development of the adipose lineage in response to endogenous lipid activators and that this factor may serve to link the process of adipocyte differentiation to systemic lipid metabolism.

3,420 citations

Journal ArticleDOI
24 Dec 1987-Cell
TL;DR: In this article, the major open reading frame encoded by this cDNA contains a short protein segment similar to a sequence present in the myc protein family, and the expression of one of these cDNAs transfected into C3H10T1/2 fibroblasts, where it is not normally expressed, is sufficient to convert them to stable myoblasts.

3,162 citations

Journal ArticleDOI
TL;DR: The EGF-MolecularWeight Form of mEGF and the Synthesis of Extracellular Macromolecules, and the Biological Effects of EGF and Urogastrone are presented.
Abstract: During the course of purifying nerve growth factor from the submaxillary gland of the mouse, Cohen (1960) and Levi-Montalcini and Cohen (1960) noticed that daily injections of certain gland extract fractions into newborn mice produced developmental changes that could not be ascribed to nerve growth factor. These changes included precocious opening of the eyelids (7 days compared to the usual 14 days) and a similar early eruption of the incisors. Using these gross anatomical changes as an assay, Cohen (1962) proceeded to isolate the active factor — a polypeptide which he termed epidermal growth factor (EGF).

2,724 citations