Oleksandr H. Minchenko

TL;DR: The results indicate that testis‐specific form of PFKFB or PFK‐2/FBPase‐2 is also expressed in several cancer cell lines and that hypoxia induces transcription of PKFB4 gene in these cell lines by HIF‐1α dependent mechanism.

TL;DR: Overexpression of PFKFB-4 transcript levels in breast and colon malignant tumors correlates with enhanced expression of PKFB-3, hypoxia-inducible factor (HIF)-1alpha and known HIF-1 dependent genes glucose transporter 1 (Glut1) and vascular endothelial growth factor (VEGF).

TL;DR: EREG may contribute to glioma progression under the control of IRE1α, as exemplified here by the autocrine proliferation loop mediated in U87 cells by the growth factor through ErbB1.

TL;DR: Evidence is provided that PFKFB-4 and PFKfb-3 genes are also expressed in gastric and pancreatic cancer cells, they strongly respond to hypoxia via a HIF-1alpha dependent mechanism and, together with the expression of PFK FB-1 and PKFB-2 genes, possibly have a significant role in the Warburg effect which is found in malignant cells.

TL;DR: Overexpression of different PFKFB in pancreatic and gastric cancer cells under hypoxic condition is correlated with enhanced expression of vascular endothelial growth factor (VEGF) and Glut1 mRNA as well as with increased level of HIF-1α protein.