O
Olga D. Zakharova
Researcher at Russian Academy of Sciences
Publications - 72
Citations - 994
Olga D. Zakharova is an academic researcher from Russian Academy of Sciences. The author has contributed to research in topics: Tyrosyl-DNA Phosphodiesterase 1 & Phosphodiesterase. The author has an hindex of 16, co-authored 70 publications receiving 798 citations.
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Journal ArticleDOI
Synthesis and biological evaluation of novel tyrosyl-DNA phosphodiesterase 1 inhibitors with a benzopentathiepine moiety.
Alexandra L. Zakharenko,T. M. Khomenko,T. M. Khomenko,Svetlana Zhukova,Olga A. Koval,Olga A. Koval,Olga D. Zakharova,Rashid O. Anarbaev,Rashid O. Anarbaev,Natalya Sh. Lebedeva,Natalya Sh. Lebedeva,Dina V. Korchagina,Nina I. Komarova,Vladimir Vasiliev,Jóhannes Reynisson,Konstantin P. Volcho,Konstantin P. Volcho,Nariman F. Salakhutdinov,Nariman F. Salakhutdinov,Olga I. Lavrik,Olga I. Lavrik +20 more
TL;DR: The study of cytotoxicity of these compounds revealed that all compounds cause an apoptotic cell death in MCF-7 and Hep G2 cells, therefore the new class of very effective inhibitors of TDP1 was elaborated.
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New inhibitors of tyrosyl-DNA phosphodiesterase I (Tdp 1) combining 7-hydroxycoumarin and monoterpenoid moieties
T. M. Khomenko,Alexandra L. Zakharenko,Tatyana Odarchenko,Homayon J. Arabshahi,Victoriya Sannikova,Olga D. Zakharova,Dina V. Korchagina,Jóhannes Reynisson,Konstantin P. Volcho,Nariman F. Salakhutdinov,Olga I. Lavrik,Olga I. Lavrik +11 more
TL;DR: The ability of the new compounds to enhance the cytotoxicity of camptothecin, an established topoisomerase 1 poison, was demonstrated.
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High affinity interaction of HIV-1 integrase with specific and non-specific single-stranded short oligonucleotides
Anne Caumont,Gordon Jamieson,Vaea Richard de Soultrait,Vincent Parissi,Michel Fournier,Olga D. Zakharova,Roman Bayandin,Simon Litvak,Laura Tarrago-Litvak,Georgy A. Nevinsky +9 more
TL;DR: The studies on the interaction of IN with ODNs showed that in the presence of specific ODNs the activity of the enzyme was enhanced, a result which suggests an ODN‐induced conformational change of HIV‐1 IN.
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Novel tyrosyl-DNA phosphodiesterase 1 inhibitors enhance the therapeutic impact of topoteсan on in vivo tumor models.
Alexandra L. Zakharenko,Olga A. Luzina,D. N. Sokolov,V. I. Kaledin,Valery P. Nikolin,Nelly A. Popova,Jinal Patel,Olga D. Zakharova,Arina A Chepanova,Ayesha Zafar,Jóhannes Reynisson,Euphemia Leung,Ivanhoe K. H. Leung,Konstantin P. Volcho,N.F. Salakhutdinov,Olga I. Lavrik,Olga I. Lavrik +16 more
TL;DR: The results presented here justify compound 20d to be considered as a drug lead for antitumor therapy and increased the effect of topotecan both in vitro and in vivo in the Lewis lung carcinoma model.
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HIV-1 integrase-hydrolyzing IgM antibodies from sera of HIV-infected patients.
Svetlana V. Baranova,Valentina N. Buneva,Valentina N. Buneva,Marina A. Kharitonova,Ludmila P. Sizyakina,Christina Calmels,Marie-Line Andreola,Vincent Parissi,Olga D. Zakharova,Georgy A. Nevinsky,Georgy A. Nevinsky +10 more
TL;DR: Evidence is presented showing that 22 of 24 IgMs purified from the sera of HIV-infected patients specifically hydrolyze only HIV IN but not many other tested proteins, indicating that detection of IN-hydrolyzing activity can be useful for diagnostic purposes and for assessment of the immune status in AIDS patients.