O
Olga Safrina
Researcher at University of California, Irvine
Publications - 18
Citations - 4395
Olga Safrina is an academic researcher from University of California, Irvine. The author has contributed to research in topics: Mutation (genetic algorithm) & Voltage-dependent calcium channel. The author has an hindex of 11, co-authored 18 publications receiving 4209 citations. Previous affiliations of Olga Safrina include University of California, Berkeley.
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Journal ArticleDOI
STIM1, an essential and conserved component of store-operated Ca2+ channel function
Jack Roos,Paul J. Digregorio,Andriy V. Yeromin,Kari Lynn Ohlsen,Maria I. Lioudyno,Shenyuan L. Zhang,Olga Safrina,J. Ashot Kozak,Steven L. Wagner,Michael D. Cahalan,Gonul Velicelebi,Kenneth A. Stauderman +11 more
TL;DR: It is proposed that STIM1, a ubiquitously expressed protein that is conserved from Drosophila to mammalian cells, plays an essential role in SOC influx and may be a common component of SOC and CRAC channels.
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Genome-wide RNAi screen of Ca(2+) influx identifies genes that regulate Ca(2+) release-activated Ca(2+) channel activity.
Shenyuan L. Zhang,Andriy V. Yeromin,Xiang Zhang,Ying Yu,Olga Safrina,Aubin Penna,Jack Roos,Kenneth A. Stauderman,Michael D. Cahalan +8 more
TL;DR: Using an unbiased genome-wide RNA interference screen in Drosophila S2 cells, 75 hits are identified that strongly inhibited Ca(2+) influx upon store emptying by thapsigargin, including Stim and olf186-F, a member of a highly conserved family of four-transmembrane spanning proteins with homologs from Caenorhabditis elegans to human.
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Imaging the Single Cell Dynamics of CD4+ T Cell Activation by Dendritic Cells in Lymph Nodes
TL;DR: Observations suggest that the immunological synapse in native tissues is remarkably fluid, and that stable synapses form only at specific stages of antigen presentation to T cells, which implies that T cells activate by way of multiple antigen recognition events.
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The CRAC channel consists of a tetramer formed by Stim-induced dimerization of Orai dimers
Aubin Penna,Angelo Demuro,Andriy V. Yeromin,Shenyuan L. Zhang,Olga Safrina,Ian Parker,Michael D. Cahalan +6 more
TL;DR: It is shown that Orai is predominantly a dimer in the plasma membrane under resting conditions, which represents a new mechanism in which assembly and activation of the functional ion channel are mediated by the same triggering molecule.
Journal ArticleDOI
Orai1 and STIM1 Move to the Immunological Synapse and Are Up-Regulated during T Cell Activation
Maria I. Lioudyno,J. Ashot Kozak,Aubin Penna,Olga Safrina,Shenyuan L. Zhang,Debasish Sen,Jack Roos,Kenneth A. Stauderman,Michael D. Cahalan +8 more
TL;DR: It is shown that STIM1 and Orai1 are recruited to the immunological synapse between primary human T cells and autologous dendritic cells, implying a positive feedback loop in which an initial TCR signal favors up-regulation of STIM 1 and ORAi proteins that would augment Ca2+ signaling during subsequent antigen encounter.