Olga Zhuchenko

TL;DR: It is concluded that a small polyglutamine expansion in the human α1A calcium channel is most likely the cause of a newly classified autosomal dominant spinocerebellar ataxia, SCA6.

TL;DR: In this article, the authors have isolated a human gene termed RIGUI that encodes a bHLH/PAS protein 44% homologous to Drosophila period.

TL;DR: An apparent innate immune function in social amoebae, and the use of TirA for bacterial feeding, suggest an ancient cellular foraging mechanism that may have been adapted to defense functions well before the diversification of the animals.

TL;DR: Investigation of ion channel function in Spinocerebellar ataxia type 6 patients showed that Ca2+channels from SCA6 patients display near-normal biophysical properties but increased current density attributable to elevated protein expression at the cell surface, which is not a consequence of changes in RNA stability.

TL;DR: This work reports that Sentinel (S) cells of the multicellular slug stage of the social amoeba Dictyostelium discoideum produce ETs upon stimulation with bacteria or lipopolysaccharide in a reactive oxygen species-dependent manner, and suggests that the origin of DNA-based ETs as an innate immune defence predates the emergence of metazoans.