O
Oliver Hartmann
Researcher at University of Würzburg
Publications - 8
Citations - 85
Oliver Hartmann is an academic researcher from University of Würzburg. The author has contributed to research in topics: DNA damage & Cancer. The author has an hindex of 2, co-authored 8 publications receiving 24 citations.
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Journal ArticleDOI
Maintaining protein stability of ∆Np63 via USP28 is required by squamous cancer cells
Cristian Prieto-Garcia,Oliver Hartmann,Michaela Reissland,Fabian Braun,Thomas Fischer,Susanne Walz,Christina Schülein-Völk,Ursula Eilers,Carsten P. Ade,Marco A. Calzado,Amir Orian,Hans Michael Maric,Christian Münch,Mathias T. Rosenfeldt,Martin Eilers,Markus E. Diefenbacher +15 more
TL;DR: It is reported that the deubiquitylase USP28 stabilizes ∆Np63 and maintains elevated ∆NP63 levels in SCC by counteracting its proteasome‐mediated degradation.
Journal ArticleDOI
Implementation of CRISPR/Cas9 Genome Editing to Generate Murine Lung Cancer Models That Depict the Mutational Landscape of Human Disease.
Oliver Hartmann,Michaela Reissland,Carina R. Maier,Thomas Fischer,Cristian Prieto-Garcia,Cristian Prieto-Garcia,Apoorva Baluapuri,Jessica Denise Schwarz,Werner Schmitz,Martín Garrido-Rodríguez,Nikolett Pahor,Clare C. Davies,Florian Bassermann,Amir Orian,Elmar Wolf,Almut Schulze,Marco A. Calzado,Mathias T. Rosenfeldt,Markus E. Diefenbacher +18 more
TL;DR: In this paper, the authors used CRISPR/Cas9-mediated targeting of Trp53 and KRas in lung cancer patients to develop tumor models with similar morphology, marker expression and transcriptional profiles.
Journal ArticleDOI
Inhibition of USP28 overcomes Cisplatin-resistance of squamous tumors by suppression of the Fanconi anemia pathway.
Cristian Prieto-Garcia,Oliver Hartmann,Michaela Reissland,Thomas Fischer,Carina R. Maier,Mathias Rosenfeldt,Christina Schülein-Völk,Kevin Klann,Reinhard Kalb,Ivan Dikic,Christian Münch,Markus E. Diefenbacher +11 more
TL;DR: In this article, the deubiquitylase USP28 is recruited to sites of DNA damage in cisplatin-treated cells, which stabilizes ∆Np63.
Posted ContentDOI
Inhibition of USP28 overcomes Cisplatin-Resistance of Squamous Tumors by Suppression of the Fanconi Anemia Pathway
Cristian Prieto-Garcia,Oliver Hartmann,Michaela Reissland,Thomas Fischer,Carina R. Maier,Mathias Rosenfeldt,Christina Schuelein-Voelk,Kevin Klann,Reinhard Kalb,Ivan Dikic,C. Muench,Markus E. Diefenbacher +11 more
TL;DR: This study reports that the deubiquitylase USP28 affects the FA DNA repair pathway during cisplatin treatment in SCC, thereby influencing therapy outcome, and presents a novel mechanism by which tumor cells, and in particular ΔNp63 expressing S CC, can be targeted to overcome chemotherapy resistance.
Posted ContentDOI
The USP28-{triangleup}Np63 axis is a vulnerability of squamous tumours
Cristian Prieto-Garcia,Oliver Hartmann,Michaela Reissland,Fabian Braun,Thomas Fischer,Susanne Walz,A. Fischer,Marco A. Calzado,Amir Orian,Mathias T. Rosenfeldt,Martin Eilers,Markus E. Diefenbacher +11 more
TL;DR: In this paper, the deubiquitylase USP28 stabilizes Np63 protein and maintains elevated levels in SCC by counteracting its proteasome-mediated degradation.