O
Olivera J. Finn
Researcher at University of Pittsburgh
Publications - 9
Citations - 562
Olivera J. Finn is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Glycopeptide & Antigen. The author has an hindex of 6, co-authored 9 publications receiving 529 citations.
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Book ChapterDOI
MUC1 immunobiology: from discovery to clinical applications.
Journal ArticleDOI
Conditions Associated with Antibodies Against the Tumor-Associated Antigen MUC1 and Their Relationship to Risk for Ovarian Cancer
Daniel W. Cramer,Linda Titus-Ernstoff,John McKolanis,William R. Welch,Allison F. Vitonis,Ross S. Berkowitz,Olivera J. Finn +6 more
TL;DR: Several traditional and new risk factors for ovarian cancer may be explained by their ability to induce M UC1 immunity through exposure of MUC1 to immune recognition in the context of inflammatory or hormonal processes in various MUC2-positive tissues.
Journal ArticleDOI
Epidemiologic perspective on immune-surveillance in cancer.
Daniel W. Cramer,Olivera J. Finn +1 more
TL;DR: It is proposed that most of these events affect cancer immunosurveillance by changing the balance between an effective immune response and immune tolerance of an emerging cancer.
Journal ArticleDOI
Tumor-associated MUC1 glycopeptide epitopes are not subject to self-tolerance and improve responses to MUC1 peptide epitopes in MUC1 transgenic mice.
TL;DR: It is shown that immunization with the 100 amino acid-long VNTR peptide (MUC1p) elicits weaker responses in MUC1 transgenic mice compared to wild type mice suggesting self-tolerance, and it is concluded that M UC1 glycopeptides induce stronger immunity in Muc1-Tg mice because they are recognized as `foreign' rather than `self' andBecause they are cross-presented preferentially by DCs.
Journal ArticleDOI
Tumor Antigen Epitopes Interpreted by the Immune System as Self or Abnormal-Self Differentially Affect Cancer Vaccine Responses
TL;DR: The immune system differentially recognizes various epitopes of tumor-associated antigens either as self or as foreign, and this controls the strength of antitumor immunity, which represents an important consideration for designing safe and effective cancer vaccines.