O
Olivier Boss
Researcher at Beth Israel Deaconess Medical Center
Publications - 49
Citations - 18754
Olivier Boss is an academic researcher from Beth Israel Deaconess Medical Center. The author has contributed to research in topics: Brown adipose tissue & Uncoupling protein. The author has an hindex of 34, co-authored 49 publications receiving 17881 citations. Previous affiliations of Olivier Boss include University of Geneva & Harvard University.
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Journal ArticleDOI
Resveratrol improves health and survival of mice on a high-calorie diet
Joseph A. Baur,Kevin J. Pearson,Nathaniel O Price,Hamish A. Jamieson,Carles Lerin,Avash Kalra,Vinayakumar Prabhu,Joanne S. Allard,Guillermo López-Lluch,Kaitlyn N. Lewis,Paul J. Pistell,Suresh Poosala,Kevin G. Becker,Olivier Boss,Dana M. Gwinn,Mingyi Wang,Sharan Ramaswamy,Kenneth W. Fishbein,Richard G. Spencer,Edward G. Lakatta,David G. Le Couteur,Reuben J. Shaw,Plácido Navas,Pere Puigserver,Donald K. Ingram,Rafael de Cabo,David A. Sinclair +26 more
TL;DR: It is shown that resveratrol shifts the physiology of middle-aged mice on a high-calorie diet towards that of mice onA standard diet and significantly increases their survival and point to new approaches for treating obesity-related disorders and diseases of ageing.
Journal ArticleDOI
Transcriptional co-activator PGC-1α drives the formation of slow-twitch muscle fibres
Jiandie D. Lin,Hai Wu,Paul T. Tarr,Chen-Yu Zhang,Zhidan Wu,Olivier Boss,Laura F. Michael,Pere Puigserver,Elji Isotani,Eric N. Olson,Bradford B. Lowell,Rhonda S Bassel-Duby,Bruce M. Spiegelman +12 more
TL;DR: Using fibre-type-specific promoters, it is shown in cultured muscle cells that PGC-1α activates transcription in cooperation with Mef2 proteins and serves as a target for calcineurin signalling, which has been implicated in slow fibre gene expression.
Journal ArticleDOI
Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes
Jill C. Milne,Philip D. Lambert,Simon Schenk,David P. Carney,J. Joshua Smith,David J. Gagne,Lei Jin,Olivier Boss,Robert B. Perni,Chi B. Vu,Jean Bemis,Roger Xie,Jeremy S. Disch,Pui Yee Ng,Joseph J. Nunes,Amy V. Lynch,Hongying Yang,Heidi Galonek,Kristine Israelian,Wendy Choy,Andre Iffland,Siva Lavu,Oliver Medvedik,David A. Sinclair,Jerrold M. Olefsky,Michael R. Jirousek,Peter J. Elliott,Christoph H. Westphal +27 more
TL;DR: These compounds bind to the SIRT1 enzyme–peptide substrate complex at an allosteric site amino-terminal to the catalytic domain and lower the Michaelis constant for acetylated substrates and improve whole-body glucose homeostasis and insulin sensitivity in adipose tissue, skeletal muscle and liver.
Journal ArticleDOI
Increased Energy Expenditure, Decreased Adiposity, and Tissue-Specific Insulin Sensitivity in Protein-Tyrosine Phosphatase 1B-Deficient Mice
Lori D. Klaman,Olivier Boss,Odile D. Peroni,Jason K. Kim,Jennifer L. Martino,Janice M. Zabolotny,Nadeem Moghal,Margaret Lubkin,Young-Bum Kim,Arlene H. Sharpe,Alain Stricker-Krongrad,Gerald I. Shulman,Benjamin G. Neel,Barbara B. Kahn +13 more
TL;DR: PTP-1B is identified as a major regulator of energy balance, insulin sensitivity, and body fat stores in vivo and is implicated in the regulation of insulin action and signal transduction pathways.
Journal ArticleDOI
Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver
E. Dale Abel,Odile D. Peroni,Jason K. Kim,Young-Bum Kim,Olivier Boss,Ed Hadro,Timo Minnemann,Gerald I. Shulman,Barbara B. Kahn +8 more
TL;DR: Downregulation of GLUT4 and glucose transport selectively in adipose tissue can cause insulin resistance and thereby increase the risk of developing diabetes, as well as developing glucose intolerance and hyperinsulinaemia.