Olivier Gagey

Bio: Olivier Gagey is an academic researcher from Université Paris-Saclay. The author has contributed to research in topics: Iliocostalis & Femoral neck. The author has an hindex of 13, co-authored 29 publications receiving 466 citations. Previous affiliations of Olivier Gagey include University of Orléans & University of Paris-Sud.

The Functional Role of the Triceps Surae Muscle during Human Locomotion

Abstract: AIM: Despite numerous studies addressing the issue, it remains unclear whether the triceps surae muscle group generates forward propulsive force during gait, commonly identified as 'push-off'. In order to challenge the push-off postulate, one must probe the effect of varying the propulsive force while annulling the effect of the progression velocity. This can be obtained by adding a load to the subject while maintaining the same progression velocity. METHODS: Ten healthy subjects initiated gait in both unloaded and loaded conditions (about 30% of body weight attached at abdominal level), for two walking velocities, spontaneous and fast. Ground reaction force and EMG activity of soleus and gastrocnemius medialis and lateralis muscles of the stance leg were recorded. Centre of mass velocity and position, centre of pressure position, and disequilibrium torque were calculated. RESULTS: At spontaneous velocity, adding the load increased disequilibrium torque and propulsive force. However, load had no effect on the vertical braking force or amplitude of triceps activity. At fast progression velocity, disequilibrium torque, vertical braking force and triceps EMG increased with respect to spontaneous velocity. Still, adding the load did not further increase braking force or EMG. CONCLUSIONS: Triceps surae is not responsible for the generation of propulsive force but is merely supporting the body during walking and restraining it from falling. By controlling the disequilibrium torque, however, triceps can affect the propulsive force through the exchange of potential into kinetic energy.

The natural course of low back pain: a systematic critical literature review

Abstract: Most patients in the secondary care sector consulting for low back pain (LBP) seem to have a more or less constant course of pain during the ensuing year. Fewer patients with LBP in the primary care sector report continual pain over a one-year period. However, not much is known about the long-term course of LBP in the general population. A systematic critical literature review was undertaken in order to study the natural course of LBP over time in the general population. A search of articles was performed in Pubmed, Cinahl and Psychinfo using the search terms ‘epidemiology’; ‘low back pain’ or ‘back pain’; ‘prospective study’ or ‘longitudinal study’; ‘follow-up’, ‘natural course’, ‘course’ or ‘natural history’; ‘general population’ or ‘working population’. Inclusion criteria were that one of the objectives was to study the course of (L)BP in the adult population, that the period of follow-up was at least 3 months, and that there were three points of observation or more. The review was undertaken by two independent reviewers using three checklists relating to description of studies, quality and outcomes. The course of LBP was established in relation to those who, at baseline, were reported not to have LBP or to have LBP. Would this course be stable, fluctuating, worsening, or improving over time? A synthesis of results in relation to common patterns was presented in a table and interpreted in a narrative form. Eight articles were included. Articles were different on time span, the number of surveys, and the definition of LBP. In six of the seven relevant studies, for those with no LBP at baseline, relatively substantial stable subgroups of people who continued to be LBP free were identified. In six of the seven relevant studies, definite stable subgroups of continued LBP were noted and improvement (becoming pain free) was never reported to be a common finding. The status of LBP in individuals of the general population appears to be relatively stable over time, perhaps particularly so for those without LBP at baseline.

Comparison of Percutaneous Dorsal Versus Volar Fixation of Scaphoid Waist Fractures Using a Computer Model in Cadavers

Abstract: Purpose Percutaneous screw fixation (PSF) is widely used to treat acute nondisplaced scaphoid waist fractures. PSF can be performed through a volar or dorsal approach. The aim of our study was to compare a dorsal versus volar surgical approach for PSF according to the sagittal orientation of the waist fracture (B1 or B2 in Herbert and Fisher's classification scheme, in which B1 and B2 designate, respectively, oblique and transverse nondisplaced scaphoid waist fractures) on computer modeling of cadaver wrists. Methods We used 12 upper limbs, and for each wrist we performed 3 computed tomography scans in maximal flexion, neutral position, and maximal extension. For each position, a parasagittal slice corresponding to the plane of ideal screw placement was obtained by numerical reconstruction. On each slice, we modeled B1- and B2-type fractures and the placement of the corresponding screws (S1 and S2) inserted through a volar or dorsal approach. Optimal screw orientation was perpendicular to the fracture. For each configuration, we measured the angle between the S1 screw and B1 fracture, which we designated V1 when modeling volar PSF and D1 when modeling dorsal PSF. Similarly, we measured angles V2 and D2. Results For B2 fractures, virtual screw placement perpendicular to the fracture was achieved equally well with the 2 approaches. For B1 fractures, the virtual screw could not be placed perpendicular to the fracture with either approach, but the dorsal approach with maximal wrist flexion allowed the best screw placement. Conclusions For B2 fractures, the dorsal and volar approaches allow optimal virtual screw placement, and the choice of the approach depends on the surgeon's preference. For B1 fractures, we recommend the dorsal approach.

A three-dimensional axis for the study of femoral neck orientation

Abstract: A common problem in the quantification of the orientation of the femoral neck is the difficulty to determine its true axis; however, this axis is typically estimated visually only. Moreover, the orientation of the femoral neck is commonly analysed using angles that are dependent on anatomical planes of reference and only quantify the orientation in two dimensions. The purpose of this study is to establish a method to determine the three-dimensional orientation of the femoral neck using a three-dimensional model. An accurate determination of the femoral neck axis requires a reconsideration of the complex architecture of the proximal femur. The morphology of the femoral neck results from both the medial and arcuate trabecular systems, and the asymmetry of the cortical bone. Given these considerations, two alternative models, in addition to the cylindrical one frequently assumed, were tested. The surface geometry of the femoral neck was subsequently used to fit one cylinder, two cylinders and successive cross-sectional ellipses. The model based on successive ellipses provided a significantly smaller average deviation than the two other models (P < 0.001) and reduced the observer-induced measurement error. Comparisons with traditional measurements and analyses on a sample of 91 femora were also performed to assess the validity of the model based on successive ellipses. This study provides a semi-automatic and accurate method for the determination of the functional three-dimensional femoral neck orientation avoiding the use of a reference plane. This innovative method has important implications for future studies that aim to document and understand the change in the orientation of the femoral neck associated with the acquisition of a bipedal gait in humans. Moreover, the precise determination of the three-dimensional orientation has implications in current research involved in developing clinical applications in diagnosis, hip surgery and rehabilitation.

Feasibility assessment of shear wave elastography to lumbar back muscles: A Radioanatomic Study.

Abstract: Introduction: Low back pain is often associated with tensional changes in the paraspinal muscles detected by palpatory procedures Shear wave elastography (SWE), recently introduced, allows the stiffness of muscles to be assessed non-invasively The aim of our work was to study the feasibility of using SWE on the three main lumbar back muscles (multifidus, longissimus and iliocostalis) in vivo after analyzing their muscular architecture ex vivo Materials and methods: We determined the orientation of fibers in the multifidus, longissimus and iliocotalis muscles in seven fresh cadavers using gross anatomy and B-Mode ultrasound imaging We then quantified the stiffness of these three muscles at the L3 level ex vivo and in 16 healthy young adults Results: Little pennation was observed in the longissimus and iliocostalis, in which the direction of fibers was almost parallel to the line of spinous processes The multifidus appeared as a multiceps and multipennate muscle Given the random layering of millimetric fascicles, tendons and fatty spaces, the multifidus had multiple fiber orientations Muscular fascicles and fibers were oriented from 9° to 22° to the line of spinous processes The shear moduli related to stiffness were 69±27 kPa for the longissimus, 49±14 kPa for the iliocostalis and 54±16 kPa for the multifidus Conclusion: SWE is a feasible method for quantifying the stiffness of the lumbar back muscles This article is protected by copyright All rights reserved

Gray's Anatomy

Abstract: MEDICAL LITERATURE has been deluged during the past few years with books and papers on penicillin; but a book which has been produced under the general editorship of Sir Alexander Fleming himself represents a complete and authoritative summary of penicillin therapy as it stands today.' The book contains a series of independent contributions by \"experienced and eminent men who have worked with penicillin in Great Britain\". Their opinions and practical methods differ slightly, and there is some overlapping; but these are not disadvantageous, comparison and contrast lending interest to the reading. In the first or general section of the book Fleming contributes two chapters, one on the history and development of penicillin, introducing some interesting sidelights in the romance of discovery, the other on the bacteriological control of penicillin therapy. In both chapters the information is set out in meticulous detail and with a clarity and simplicity which can be enjoyed by all readers. Fleming also gives the right perspective to the place of penicillin amongst the antibiotics and lays down the principles of treatment. Both chapters are well illustrated and are the most outstanding in the book. Included in this first section also are chapters on the chemistry and manufacture of penicillin and its pharmacy, pharmacology and methods of administration. The second section of the book is entirely clinical, giving each author's view on the use of penicillin therapy in a disease or an infection of some particular region of the body. The entire range of peniCillin-sensitive conditions is considered in twenty authoritative and clearly written chapters; these contain many references and illustrations. Dental and veterinary diseases are also given fairly full consideration. The final section is a condensed resume of much of the preceding chapters and is written for. the general practttioner. This chapter is superttuous: it does not contain enough detall to be of much practical value. The book as a Whole, however, will undoubtedly be considered a classical contribution to medical literature and is strongly recommended, not only because of the general interest of its topic, but as a reference book on penicillin therapy of hitherto unequalled excellence. The typography, although conforming to war economy standards, is clear and the paper is good. There is an excellent list of references and the index is satisfactory.

What is the source of chronic low back pain and does age play a role

Abstract: Objective. The objective of this study was to estimate the prevalence, mean age, and association of prevalence and age of lumbar internal disc disruption (IDD), facet joint pain (FJP), sacroiliac joint pain (SIJP), spinal and pelvic insufficiency fractures, interspinous ligament injury/Baastrup's Disease, and soft tissue irritation by fusion hardware. Design. The study's design was a retrospective chart review. Setting. The study was set in an academic spine center. Patients. A total of 378 cases from 358 patients were reviewed of which 170 cases from 156 patients who underwent diagnostic procedures were included. Interventions. Discography, dual diagnostic facet joint blocks, intra-articular sacroiliac joint injections, anesthetic injections of painful interspinous ligaments/opposing spinous processes/posterior fusion hardware, or percutaneous augmentation were performed. Outcome Measures. Prevalence and age were analyzed for each diagnosis group. Methods. Patients with recalcitrant low back pain underwent diagnostic procedures based on their clinical presentation until the pain source was identified. Results. The prevalence of internal disc disruption, facet joint pain and sacroiliac joint pain was 42%, 31%, and 18%, respectively. Patients with internal disc disruption were significantly younger than those with facet joint pain or sacroiliac joint pain. Increased age was associated with a decreased probability of internal disc disruption and increased probabilities of facet joint pain and sacroiliac joint pain as the source of low back pain until approximately age 70. Conclusion. Our data confirm the intervertebral disc as the most common etiology of chronic low back pain in adults. Based on our sample, the younger the patient, the more likely low back pain is discogenic in origin. Facetogenic or sacroiliac joint pain is more likely in older patients.

Arrhythmias AbstractsBaroreflex sensitivity and heart rate variability in the identification of patients at risk for life-threatening arrhythmia. Implications for clinical trials

Abstract: BackgroundThe need for accurate risk stratification is heightened by the expanding indications for the implantable cardioverter defibrillator. The Multicenter Automatic Defibrillator Implantation Trial (MADIT) focused interest on patients with both depressed left ventricular ejection fraction (LVEF) and the presence of nonsustained ventricular tachycardia (NSVT). Meanwhile, the prospective study Autonomic Tone and Reflexes After Myocardial Infarction (ATRAMI) demonstrated that markers of reduced vagal activity, such as depressed baroreflex sensitivity (BRS) and heart rate variability (HRV), are strong predictors of cardiac mortality after myocardial infarction. Methods and ResultsWe analyzed 1071 ATRAMI patients after myocardial infarction who had data on LVEF, 24-hour ECG recording, and BRS. During follow-up (21±8 months), 43 patients experienced cardiac death, 5 patients had episodes of sustained VT, and 30 patients experienced sudden death and/or sustained VT. NSVT, depressed BRS, or HRV were all significantly and independently associated with increased mortality. The combination of all 3 risk factors increased the risk of death by 22×. Among patients with LVEF<35%, despite the absence of NSVT, depressed BRS predicted higher mortality (18% versus 4.6%, P =0.01). This is a clinically important finding because this group constitutes 25% of all patients with depressed LVEF. For both cardiac and arrhythmic mortality, the sensitivity of low BRS was higher than that of NSVT and HRV. ConclusionsBRS and HRV contribute importantly and additionally to risk stratification. Particularly when LVEF is depressed, the analysis of BRS identifies a large number of patients at high risk for cardiac and arrhythmic mortality who might benefit from implantable cardioverter defibrillator therapy without disproportionately increasing the number of false-positives.