O
Olivier Neyrolles
Researcher at University of Toulouse
Publications - 161
Citations - 9285
Olivier Neyrolles is an academic researcher from University of Toulouse. The author has contributed to research in topics: Mycobacterium tuberculosis & Immune system. The author has an hindex of 47, co-authored 148 publications receiving 8066 citations. Previous affiliations of Olivier Neyrolles include Imperial College London & Paul Sabatier University.
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Journal ArticleDOI
DC-SIGN Is the Major Mycobacterium tuberculosis Receptor on Human Dendritic Cells
Ludovic Tailleux,Olivier Schwartz,Jean-Louis Herrmann,Elisabeth Pivert,Mary Jackson,Ali Amara,Luc Legrès,Donatus Dreher,Laurent P. Nicod,Jean Claude Gluckman,Philippe H. Lagrange,Brigitte Gicquel,Olivier Neyrolles +12 more
TL;DR: It is shown that M. tuberculosis enters human monocyte-derived DCs after binding to the recently identified lectin DC-specific intercellular adhesion molecule-3 grabbing nonintegrin (DC-SIGN), which is likely to influence bacterial persistence and host immunity.
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Evolutionary Dynamics of Human Toll-Like Receptors and Their Different Contributions to Host Defense
Luis B. Barreiro,Luis B. Barreiro,Meriem Ben-Ali,Hélène Quach,Guillaume Laval,Etienne Patin,Etienne Patin,Joseph K. Pickrell,Christiane Bouchier,Magali Tichit,Olivier Neyrolles,Brigitte Gicquel,Judith R. Kidd,Kenneth K. Kidd,Alexandre Alcaïs,Josiane Ragimbeau,Sandra Pellegrini,Laurent Abel,Laurent Abel,Jean-Laurent Casanova,Jean-Laurent Casanova,Lluis Quintana-Murci +21 more
TL;DR: It is found that the intracellular TLRs—activated by nucleic acids and particularly specialized in viral recognition—have evolved under strong purifying selection, indicating their essential non-redundant role in host survival.
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Sexual Inequality in Tuberculosis
TL;DR: The evidence on why tuberulosis notification is twice as high in men as in women in most countries is reviewed.
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Dissection of ESAT-6 System 1 of Mycobacterium tuberculosis and Impact on Immunogenicity and Virulence
Priscille Brodin,Laleh Majlessi,Laurent Marsollier,Marien I. de Jonge,Daria Bottai,Caroline Demangel,Jason Hinds,Olivier Neyrolles,Philip D. Butcher,Claude Leclerc,Stewart T. Cole,Roland Brosch +11 more
TL;DR: ESX-1-complemented BCG and M. microti strains were more efficiently engulfed by bone-marrow-derived macrophages than controls, and this may account for the enhanced in vivo growth of ESX- 1-carrying strains.
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Mycobacterial P1-Type ATPases Mediate Resistance to Zinc Poisoning in Human Macrophages
Hélène Botella,Hélène Botella,Pascale Peyron,Pascale Peyron,Florence Levillain,Florence Levillain,Renaud Poincloux,Renaud Poincloux,Yannick Poquet,Yannick Poquet,Irène Brandli,Irène Brandli,Irène Brandli,Chuan Wang,Chuan Wang,Chuan Wang,Ludovic Tailleux,Sylvain Tilleul,Guillaume M. Charrière,Guillaume M. Charrière,Simon J. Waddell,Maria Foti,Geanncarlo Lugo-Villarino,Geanncarlo Lugo-Villarino,Qian Gao,Isabelle Maridonneau-Parini,Isabelle Maridonneau-Parini,Philip D. Butcher,Paola Ricciardi Castagnoli,Brigitte Gicquel,Chantal de Chastellier,Chantal de Chastellier,Chantal de Chastellier,Olivier Neyrolles,Olivier Neyrolles +34 more
TL;DR: The use of P1-type ATPases represents a M. tuberculosis strategy to neutralize the toxic effects of zinc in macrophages, suggesting that heavy metal toxicity and its counteraction might represent yet another chapter in the host-microbe arms race.