Orla M. Conneely

TL;DR: Results provide direct support for progesterone's role as a pleiotropic coordinator of diverse reproductive events that together ensure species survival.

TL;DR: It is demonstrated that Nurr1 functions at the later stages of dopamine cell development to drive differentiation of ventral mesencephalic late dopaminergic precursor neurons, and is essential for specifying commitment of mesENCEphalic precursors to the full dopamine phenotype.

TL;DR: Progesterone receptors PR-A and PR-B are functionally distinct mediators of progesterone action in vivo and should provide suitable targets for generation of tissue-selective progestins.

TL;DR: In vitro, dopamine faithfully mimicked the effect of progesterone by causing a translocation of chicken progestersone receptor (cPR) from cytoplasm to nucleus, and a serine residue in the cPR was identified that is not necessary for progester one-dependent activation of cPR, but is essential for dopamine activation of this receptor.

TL;DR: It is shown that selective activation of PR-A in PRBKO–/– mice is sufficient to elicit normal ovarian and uterine responses to P but results in reduced mammary gland morphogenesis, and that selective modulation ofPR-A activity by progestin agonists may have a protective effect against both uterine and mammaries hyperplasias.