Osama M. Mukdadi

Bio: Osama M. Mukdadi is an academic researcher from West Virginia University. The author has contributed to research in topics: Ultrasonic sensor & Dispersion (water waves). The author has an hindex of 14, co-authored 58 publications receiving 690 citations. Previous affiliations of Osama M. Mukdadi include Khalifa University & Office of Technology Transfer.

Patient-Specific 3D Finite-Element Analysis of Miniscrew Implants During Orthodontic Treatment

Abstract: Miniscrew implants have seen increasing clinical use as orthodontic anchorage devices with demonstrated stability. The focus of this study is to develop and simulate operative factors, such as load magnitudes and anchor locations to achieve desired motions in a patient-specific 3D model undergoing orthodontic treatment with miniscrew implant anchorage. A CT scan of a patient skull was imported into Mimics software (Materialise, 12.1). Segmentation operations were performed on the images to isolate the mandible, filter out noise, then reconstruct a smooth 3D model. A model of the left canine was reconstructed with the PDL modeled as a thin solid layer. A miniscrew was modeled with dimensions based on a clinical implant (BMK OAS-T1207) then inserted into the posterior mandible. All components were volumetrically meshed and optimized in Mimics software. Elements comprising the mandible bone and teeth were assigned a material based on their gray value ranges in HU from the original scan, and meshes were exported into ANSYS software. All materials were defined as linear and isotropic. A nonlinear PDL was also defined for comparison. For transverse forces applied on the miniscrew, maximum stresses increased linearly with loading and appeared at the neck or first thread and in the cortical bone. A distal tipping force was applied on the canine, and maximum stresses appeared in the tooth at the crown and apex and in the bone at the compression surface. Under maximum loading, stresses in bone were sufficient for resorption. The nonlinear PDL exhibited lower stresses and deflections than the linear model due to increasing stiffness. Numerous stress concentrations were seen in all models. Results of this study demonstrate the potential of patient-specific 3D reconstruction from CT scans and finite-element simulation as a versatile and effective pre-operative planning tool for orthodontists.© 2009 ASME

High frequency 3D echodentographic imaging modality for early assessment of periodontal diseases: in vitro study

Abstract: The use of ultrasound in dentistry is still an open growing area of research. Currently, there is a lack of imaging modalities to accurately predict minute structures and defects in the jawbone. In particular, the inability of 2D radiographic images to detect bony periodontal defects resulted from infection of the periodontium. This study investigates the feasibility of high frequency ultrasound to reconstruct high resolution 3D surface images of human jawbone. Methods: A dentate and non-dentate mandibles were used in this study. The system employs high frequency single-element ultrasound focused transducers (15-30 MHz) for scanning. Continuous acquisition using a 1 GHz data acquisition card is synchronized with a high precision two-dimensional stage positioning system of ±1 µm resolution for acquiring accurate and quantitative measurements of the mandible in vitro. Radio frequency (RF) signals are acquired laterally 44-45.5 µm apart for each frame. Different frames are reconstructed 500 µm apart for the 3D reconstruction. Signal processing algorithms are applied on the received ultrasound signals for filtering, focusing, and envelope detection before frame reconstruction. Furthermore, an edge detection technique is adopted to detect the bone surface in each frame. Finally, all edges are combined together in order to render a 3D surface image of the jawbone. Major anatomical landmarks on the resultant images were confirmed with the anatomical structures on the mandibles to show the efficacy of the system. Comparison were also made with conventional 2D radiographs to show the superiority of the ultrasound imaging system in diagnosing small defects in the lateral, axial and elevation planes of space. Results: The landmarks on all ultrasound images matched with those on the mandible, indicating the efficacy of the system in detecting small structures in human jaw bones. Comparison with conventional 2D radiographic images of the same mandible showed superiority of the 3D ultrasound images in detecting defects in the elevation plane of space. These results suggest that the high frequency ultrasound system shows great potential in providing a non-invasive method to characterize the jawbone and detect periodontal diseases at earlier stages.

Guided Acoustic Phonon Modes in Layered Anisotropic Nanowires

Abstract: Acoustic phonons play a critical role in energy transport in nanostructures. The dispersion of acoustic phonons strongly influences thermal conductivity. Recent observations show lower values of thermal conductivity in finite dimensional nanostructures than in the bulk material. In this work, we will present results for guided acoustic phonon modes in (a) a bilayered GaAs-Nb nanowire of rectangular cross section and (b) a trapezoidal Si nanowire. The former has been used for phonon counting in a nanocalorimeter for measuring thermal conductivity and the latter is commonly used in MEMS applications. A semi-analytical finite element (SAFE) analysis technique has been used to investigate the effects of layering, anisotropy, and boundaries on the dispersion of modes of propagation. Many interesting features of group velocities are found that show confinements around the corners, in the low velocity layer, and coupling of the longitudinal and flexural modes. These would strongly influence thermal conductivity and might provide means of nondestrutive evaluation of mechanical properties.Copyright © 2003 by ASME

Ultrasonic imaging and prediction of orthotropic plate stiffness in all planar directions

Abstract: Exact and approximate theoretical analysis of the wavelengths of plate wave mode propagation in all planar directions for the dispersive antisymmetric Lamb wave mode are compared with measurements from a laser ultrasonic imaging approach that records the out of plane ultrasonic motion over a large area in a single frame without scanning. Good agreement is demonstrated, based on independent determination of the elastic constants, for two different types of paper.

Relation of tumor size, lymph node status, and survival in 24,740 breast cancer cases

Abstract: Two of the most important prognostic indicators for breast cancer are tumor size and extent of axillary lymph node involvement. Data on 24,740 cases recorded in the Surveillance, Epidemiology, and End Results (SEER) Program of the National Cancer Institute were used to evaluate the breast cancer survival experience in a representative sample of women from the United States. Actuarial (life table) methods were used to investigate the 5-year relative survival rates in cases with known operative/pathologic axillary lymph node status and primary tumor diameter. Survival rates varied from 45.5% for tumor diameters equal to or greater than 5 cm with positive axillary nodes to 96.3% for tumors less than 2 cm and with no involved nodes. The relation between tumor size and lymph node status was investigated in detail. Tumor diameter and lymph node status were found to act as independent but additive prognostic indicators. As tumor size increased, survival decreased regardless of lymph node status; and as lymph node involvement increased, survival status also decreased regardless of tumor size. A linear relation was found between tumor diameter and the percent of cases with positive lymph node involvement. The results of our analyses suggest that disease progression to distant sites does not occur exclusively via the axillary lymph nodes, but rather that lymph node status serves as an indicator of the tumor's ability to spread.

Nanoparticles as contrast agents for in-vivo bioimaging: current status and future perspectives

Abstract: Nanoparticle-based contrast agents are quickly becoming valuable and potentially transformative tools for enhancing medical diagnostics for a wide range of in-vivo imaging modalities. Compared with conventional molecular-scale contrast agents, nanoparticles (NPs) promise improved abilities for in-vivo detection and potentially enhanced targeting efficiencies through longer engineered circulation times, designed clearance pathways, and multimeric binding capacities. However, NP contrast agents are not without issues. Difficulties in minimizing batch-to-batch variations and problems with identifying and characterizing key physicochemical properties that define the in-vivo fate and transport of NPs are significant barriers to the introduction of new NP materials as clinical contrast agents. This manuscript reviews the development and application of nanoparticles and their future potential to advance current and emerging clinical bioimaging techniques. A focus is placed on the application of solid, phase-separated materials, for example metals and metal oxides, and their specific application as contrast agents for in-vivo near-infrared fluorescence (NIRF) imaging, magnetic resonance imaging (MRI), positron emission tomography (PET), computed tomography (CT), ultrasound (US), and photoacoustic imaging (PAI). Clinical and preclinical applications of NPs are identified for a broad spectrum of imaging applications, with commentaries on the future promise of these materials. Emerging technologies, for example multifunctional and theranostic NPs, and their potential for clinical advances are also discussed.