O
Osman N. Ozes
Researcher at Indiana University
Publications - 31
Citations - 3656
Osman N. Ozes is an academic researcher from Indiana University. The author has contributed to research in topics: Kinase & Phosphorylation. The author has an hindex of 13, co-authored 31 publications receiving 3541 citations. Previous affiliations of Osman N. Ozes include University of California, San Francisco.
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Journal ArticleDOI
NF-κB activation by tumour necrosis factor requires the Akt serine–threonine kinase
Osman N. Ozes,Lindsey D. Mayo,Jason A. Gustin,Susan R. Pfeffer,Lawrence M. Pfeffer,David B. Donner +5 more
TL;DR: It is shown that the Akt serine–threonine kinase is involved in the activation of NF-κB by tumour necrosis factor (TNF), and that Akt is part of a signalling pathway that is necessary for inducing key immune and inflammatory responses.
Journal ArticleDOI
A phosphatidylinositol 3-kinase/Akt/mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1
Osman N. Ozes,Hakan Akca,Lindsey D. Mayo,Jason A. Gustin,Tomohiko Maehama,Jack E. Dixon,David B. Donner +6 more
TL;DR: The results suggest that TNF impairs insulin signaling through IRS-1 by activation of a PI 3-kinase/Akt/mTOR pathway, which is antagonized by PTEN.
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Cell Type-specific Expression of the IκB Kinases Determines the Significance of Phosphatidylinositol 3-Kinase/Akt Signaling to NF-κB Activation
Jason A. Gustin,Osman N. Ozes,Hakan Akca,Roxana Pincheira,Lindsey D. Mayo,Qiutang Li,Javier Rivera Guzman,Chandrashekhar K. Korgaonkar,David B. Donner +8 more
TL;DR: Noncoordinate expression of IκB kinases plays a role in determining the cell type-specific role of Akt in NF-κB activation in transformed, immortalized, and primary cells.
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Tumor Necrosis Factor Employs a Protein-tyrosine Phosphatase to Inhibit Activation of KDR and Vascular Endothelial Cell Growth Factor-induced Endothelial Cell Proliferation
Dan Qun Guo,Li Wha Wu,James D. Dunbar,Osman N. Ozes,Lindsey D. Mayo,Kelly M. Kessler,Jason A. Gustin,Melinda R. Baerwald,Eric A. Jaffe,Robert S. Warren,David B. Donner +10 more
TL;DR: Heterologous receptor inactivation mediated by a protein-tyrosine phosphatase provides insight into how TNF may inhibit endothelial cell proliferative responses and modulate angiogenesis in pathological settings.
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A comparison of interferon-Con1 with natural recombinant interferons-α : antiviral, antiproliferative, and natural killer-inducing activities
TL;DR: The results would suggest that IFN-Con1 may be more effective at lower protein concentrations in clinical applications than other available IFNs.