O
Otávio Augusto Chaves
Researcher at SENAI
Publications - 66
Citations - 1001
Otávio Augusto Chaves is an academic researcher from SENAI. The author has contributed to research in topics: Human serum albumin & Circular dichroism. The author has an hindex of 14, co-authored 53 publications receiving 588 citations. Previous affiliations of Otávio Augusto Chaves include University of Coimbra & Instituto Militar de Engenharia.
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Journal ArticleDOI
Binding studies of lophirone B with bovine serum albumin (BSA): Combination of spectroscopic and molecular docking techniques
Otávio Augusto Chaves,Veridiana A. da Silva,Carlos Mauricio R. Sant'Anna,Aurélio B. B. Ferreira,Tereza A. N. Ribeiro,Tereza A. N. Ribeiro,Mário Geraldo de Carvalho,Dari Cesarin-Sobrinho,José Carlos Netto-Ferreira,José Carlos Netto-Ferreira +9 more
TL;DR: Lophirone B seems to be exposed to the aqueous media as well as accommodated inside the protein cavity, resulting in a moderate affinity for the albumin.
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Evaluation by fluorescence, STD-NMR, docking and semi-empirical calculations of the o-NBA photo-acid interaction with BSA
Otávio Augusto Chaves,Catarina S. H. Jesus,Pedro F. Cruz,Carlos Mauricio R. Sant'Anna,Rui M. M. Brito,Rui M. M. Brito,Carlos Serpa +6 more
TL;DR: To detect potential specific or nonspecific interactions between o-NBA and BSA, ligand-binding studies are performed using fluorescence spectroscopy, saturation transfer difference (STD) NMR, molecular docking and semi-empirical calculations.
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Fluorescence and Docking Studies of the Interaction between Human Serum Albumin and Pheophytin.
Otávio Augusto Chaves,Ana Paula de O. Amorim,Larissa Henriques Evangelista Castro,Carlos Mauricio R. Sant'Anna,Márcia C.C. de Oliveira,Dari Cesarin-Sobrinho,José Carlos Netto-Ferreira,José Carlos Netto-Ferreira,Aurélio B. B. Ferreira +8 more
TL;DR: In this paper, the association constants and thermodynamic parameters for the interaction of HSA with pheophytin from Talinum triangulare were studied by UV-Vis absorption, fluorescence techniques, and molecular modeling (docking).
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Probing the interaction between 7-O-β-d-glucopyranosyl-6-(3-methylbut-2-enyl)-5,4′-dihydroxyflavonol with bovine serum albumin (BSA)
Otávio Augusto Chaves,Dari Cesarin-Sobrinho,Carlos Mauricio R. Sant'Anna,Mário Geraldo de Carvalho,Luciano R. Suzart,Francisco Eduardo Aragão Catunda-Junior,José Carlos Netto-Ferreira,José Carlos Netto-Ferreira,Aurélio B. B. Ferreira +8 more
TL;DR: In this article, the authors examined the interaction of bovine serum albumin (BSA) with glycosylated flavonol (PF) in a PBS buffer solution (pH = 7.4).
Journal ArticleDOI
Thiosemicarbazones as inhibitors of tyrosinase enzyme.
Mariana A. Soares,Mariana A. Almeida,Carla Marins-Goulart,Otávio Augusto Chaves,Aurea Echevarria,Márcia C.C. de Oliveira +5 more
TL;DR: Thio-2, containing a substituent on the aromatic ring similar to the substrate l-DOPA, showed a competitive inhibition mechanism as viewed in a Lineweaver-Burk plot, and the same results were observed in the UV-Vis curves.