O
Ottavia Barbieri
Researcher at University of Genoa
Publications - 67
Citations - 3161
Ottavia Barbieri is an academic researcher from University of Genoa. The author has contributed to research in topics: DLX5 & Cellular differentiation. The author has an hindex of 30, co-authored 66 publications receiving 2904 citations. Previous affiliations of Ottavia Barbieri include International Institute of Minnesota & National Cancer Research Institute.
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Journal ArticleDOI
Craniofacial, vestibular and bone defects in mice lacking the Distal-less-related gene Dlx5
Dario Acampora,Giorgio R. Merlo,Laura Paleari,Barbara Zerega,Maria Pia Postiglione,Stefano Mantero,Eva Bober,Ottavia Barbieri,Antonio Simeone,Giovanni Levi +9 more
TL;DR: The defects observed in Dlx5-/- mutant animals suggest multiple and independent roles of this gene in the patterning of the branchial arches, in the morphogenesis of the vestibular organ and in osteoblast differentiation.
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Jaw transformation with gain of symmetry after Dlx5/Dlx6 inactivation: Mirror of the past?
Annemiek Beverdam,Giorgio R. Merlo,Laura Paleari,Stefano Mantero,Francesca Genova,Ottavia Barbieri,Philippe Janvier,Giovanni Levi +7 more
TL;DR: This finding supports the notion that Dlx genes are homeotic genes associated with morphological novelty in the vertebrate lineage and first homeotic‐like transformation found in this Hox‐free region after gene inactivation.
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Curcumin inhibits prostate cancer metastasis in vivo by targeting the inflammatory cytokines CXCL1 and -2.
Peter H. Killian,Emanuel Kronski,Katharina M. Michalik,Ottavia Barbieri,Ottavia Barbieri,Simonetta Astigiano,Christian P. Sommerhoff,Ulrich Pfeffer,Andreas G. Nerlich,Beatrice E. Bachmeier,Beatrice E. Bachmeier +10 more
TL;DR: Chronic inflammation can induce a metastasis prone phenotype in prostate cancer cells by maintaining a positive proinflammatory and prometastatic feedback loop between NFκB and CXCL1/-2, and curcumin disrupts this feedback loop by the inhibition ofNFκB signaling leading to reduced metastasis formation in vivo.
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IL‐8 induces exocytosis of arginase 1 by neutrophil polymorphonuclears in nonsmall cell lung cancer
Rita Rotondo,Gaia Barisione,Luca Mastracci,Francesco Grossi,Anna Maria Orengo,Roberta Costa,Mauro Truini,Marina Fabbi,Silvano Ferrini,Ottavia Barbieri +9 more
TL;DR: Findings demonstrate a role of IL‐8 in ARG1 exocytosis by PMNs and indicate that, due at least in part to IL•8 secreted by NSCLC cells, PMNs infiltrating NSCLCs release ARG 1, which could contribute to local immune suppression.
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miR181b is induced by the chemopreventive polyphenol curcumin and inhibits breast cancer metastasis via down-regulation of the inflammatory cytokines CXCL1 and -2
Emanuel Kronski,Micol E. Fiori,Ottavia Barbieri,Ottavia Barbieri,Simonetta Astigiano,Valentina Mirisola,Peter H. Killian,Antonino Bruno,Arianna Pagani,Francesca Rovera,Ulrich Pfeffer,Christian P. Sommerhoff,Douglas M. Noonan,Andreas G. Nerlich,Laura Fontana,Beatrice E. Bachmeier +15 more
TL;DR: The effects of Curcumin on miRNA expression and its correlation to the anti‐tumorigenic properties of this natural occurring polyphenol are analyzed.