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Otto G. Berg
Researcher at University of Oregon
Publications - 8
Citations - 3122
Otto G. Berg is an academic researcher from University of Oregon. The author has contributed to research in topics: Binding site & DNA binding site. The author has an hindex of 7, co-authored 8 publications receiving 3004 citations. Previous affiliations of Otto G. Berg include Royal Institute of Technology.
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Journal ArticleDOI
Facilitated target location in biological systems
P H von Hippel,Otto G. Berg +1 more
TL;DR: This minireview has attempted to provide some overall perspective on the question of how various forms of diffusion in reduced dimensions, or diffusion within a nonspecifically bound state, can speed biological interactions beyond the limits normally set by three-dimensional diffusion processes.
Journal ArticleDOI
Selection of DNA Binding Sites by Regulatory Proteins Statistical-mechanical Theory and Application to Operators and Promoters
Otto G. Berg,Peter H. von Hippel +1 more
TL;DR: A statistical-mechanical selection theory for the sequence analysis of a set of specific DNA regulatory sites makes it possible to predict the relationship between individual base-pair choices in the site and specific activity (affinity), and shows that functional specificity is based on other properties in addition to primary sequence recognition.
Journal ArticleDOI
Diffusion-Controlled Macromolecular Interactions
Otto G. Berg,P H von Hippel +1 more
TL;DR: 3.3.1 The Spherical Case " 135 3.2 Other Geometries 141
Journal ArticleDOI
On the specificity of DNA-protein interactions.
P H von Hippel,Otto G. Berg +1 more
TL;DR: In this paper, informational (combinatorial) aspects of binding-site specification, actual recognition mechanisms, and the thermodynamics of target-site selection against a background of competing pseudospecific and non-(sequence)-specific DNA binding sites are considered.
Journal ArticleDOI
Selection of DNA binding sites by regulatory proteins. II. The binding specificity of cyclic AMP receptor protein to recognition sites.
Otto G. Berg,P H von Hippel +1 more
TL;DR: The statistical-mechanical selection theory is applied to analyze the base-pair statistics of the known recognition sequences for the cyclic AMP receptor protein (CRP) and the theoretical predictions are found to be in reasonable agreement with binding data for those sequences for which experimental binding information is available, thus lending support to the basic assumptions of the selection theory.