P. D. Marsden

Bio: P. D. Marsden is an academic researcher from University of London. The author has contributed to research in topics: Serum albumin & Tropical splenomegaly syndrome. The author has an hindex of 5, co-authored 6 publications receiving 188 citations. Previous affiliations of P. D. Marsden include Makerere University.

An investigation of tropical splenomegaly at mulago hospital, kampala, uganda.

Abstract: helpful advice and valuable criticism. I am also indebted to Professor Mary Barber, Postgraduate Medical School, London ; Dr. Jean Bradley, Fulham Hospital, London ; Dr. J. H. Darrell, Post graduate Medical School, London ; Professor A. El Ghoroury, Institute of Hygiene, Alexandria ; Dr. E. J. L. Lowbury, M.R.C. Industrial Injuries and Burns Research Unit, Birmingham ; Dr. Joan McWilliam, Royal Infirmary, Edinburgh ; Dr. L. Parker, Booth Hall Hospital, Manchester ; Dr. K. B. Rogers, the Children's Hospital, Birmingham ; Dr. J. K. Sch?nfeld, Rotterdam ; Professor R. A. Shooter, St. Bartholomew's Hospital Medical School, London ; Dr. M. Veron, Institut Pasteur, Paris ; and Dr. Josephine A. C. Weatherall, Charing Cross Hospital, London, for sending strains and showing interest in this work. REFERENCES

Chemoprophylaxis of Homozygous Sicklers with Antimalarials and Long-acting Penicillin

Abstract: Chemoprophylaxis of Homozygous Sicklers with Antimalarials and Long-acting Penicillin The results have been analysed in the following manner. The mean haemoglobin values, the dactylitis, and haemolytic crises rates for each individual per month were compared in the two groups by arranging the results in ascending order of magnitude and calculating the significance of the differences, using Kendall's method.

Splenomegaly in New Guinea.

Abstract: Seeking to determine whether there is a relationship in New Guineans between hepatic sinusoidal infiltration and splenomegaly on the one hand and malaria on the other, the authors studied 24 adults from a village protected from malaria for 5 years by 6-monthly DDT spraying and 34 adults from an unprotected village with hyperendemic malaria.It was found that clinical splenomegaly tended to be associated with greater hepatic sinusoidal infiltration among persons from the malarious village and that higher malaria antibody titres were more common in patients with splenomegaly in this village. In adults in the protected village the prevalence of malaria parasitaemia was much lower than in the malarious village and the sinusoidal infiltrates were also diminished.No associations between parasitaemia, malaria antibody titre, and hepatic sinusoidal infiltration could be demonstrated in the malarious village. The implications of these findings are discussed and the question of malaria being responsible for the marked splenomegaly encountered in tropical practice is discussed.

Albumin metabolism in hookworm anaemias.

Abstract: 17 patients infected with hookworms were used in a study of albumin metabolism and faecal albumin loss. They were compared with 9 controls. Factors relating to the use of 131 I-labelled albumin as a measure of albumin metabolism are discussed. Some doubt has recently been expressed as to whether faecal activity appearing in this method represents wholly albumin breakdown in or near the gut, or partly endogenous breakdown with subsequent secretion of iodide. The weight of evidence has indicated the former. The method of measuring salivary excretion of iodide and its fate may need elaborating. There seems to be little division of opinion about the bowel origin of excessive albumin losses. It is claimed that hookworm patients lose excessive albumin into their gut. The loss of albumin is roughly 0·1 g. per 100 hookworms of the species Necator americanus . This is equivalent to the loss of 3 ml. plasma per 100 hookworms. This figure agrees very well with other published work based on red cell losses estimated by 51 Cr. There seems to be a satisfactory correlation between albumin and plasma losses on the one hand, and numbers of hookworms harboured on the other. Female hookworms were in the preponderance (ratio 3 : 2). In Kampala only N. americanus was found. The worms were themselves devoid of radio-activity.

The Digestive System

Abstract: In this chapter, we discuss the diseases and related pathologic alterations that may be encountered in the gastrointestinal tract and associated organs of various species of laboratory animals, birds, fish, reptiles, and amphibians. Diseases of various segments of the gastrointestinal tract, the salivary glands, liver, and pancreas are discussed and categorized as inflammatory, parasitic, neoplastic, or miscellaneous. The latter category includes developmental anomalies and metabolic lesions. Due to space limitations, this presentation is not an all-inclusive review, but it does provide a rather extensive review of these lesions. We have also included a rather comprehensive literature review, with a list of references for those readers who want more detailed information with respect to specific diseases.

Malaria, anaemia and pregnancy.

Abstract: Physicians at University College Hospital in Ibadan Nigeria selected 250 initially unmarried 17-25 year old women employed at the hospital as subjects of a prospective study of the relationship between malaria anemia and 1st pregnancy. 60 women later became pregnant. Physicians gave full physical examination to each of the 250 women which included urine analysis determination of liver and spleen size and a variety of hematologic tests such as packed cell volume (PCV) and blood film for malaria parasites. The frequency of malaria parasitemia and the density of infection were higher in pregnant women (4-12 times more frequent and 1775 parasites/cubic mm respectively) than the same women prior to pregnancy or in the nonpregnant women. Plasmodium falciparum caused infection in almost all cases with P. malariae being responsible for only 4 cases. The incidence of splenomegaly was much higher in the group of pregnant women (42%) than found in the same women before pregnancy. 38 women did not take antimalaria chemoprophylaxis until that point in pregnancy when treatment was necessary and 24 (63%) of them developed hemolytic anemia (PCV <28%). On the other hand none of the 19 women who received antimalarial drugs developed hemolytic anemia but 1 did develop megaloblastic anemia in the 18th week. The hemolytic anemia occurred between weeks 16-24. In some cases PCV fell before the appearance of detectable parasite densities and hemolysis continued for 2 weeks after chloroquine therapy effectively eliminated parasites. In a country where malaria is endemic administering antimalarial drugs prophylactically throughout pregnancy is the most important antenatal treatment.

Criteria of case definition in Crohn's disease and ulcerative colitis.

Abstract: The diagnosis of inflammatory bowel disease is usually made on a combination of clinical, radiologic, endoscopic, and histologic grounds. In the differential diagnosis, endoscopy and histologic evaluation of biopsy specimens can help to make a specific diagnosis. Site of disease is important in documentation and can determine drug choice and clinical course. Disease activity indices are important to assess a patient objectively, particularly in multicentre studies. There is poor correlation between disease activity indices and macroscopic and histologic findings. The Severity Activity Index for Crohn's disease has both clinical and laboratory variables and is a valuable tool for the definition of Crohn's disease. An ulcerative colitis activity index that correlates significantly with microscopic and macroscopic scores, using both clinical symptoms and laboratory findings, is proposed.

NZW x BXSB)F1 hybrid. A model of acute lupus and coronary vascular disease with myocardial infarction.

Abstract: Both sexes of the (NZW x BXSB)F1 mice developed an early systemic lupus erythematosus-like disease. In males, the disease resembled that in the BXSB male parent and was not affected by sex hormonal manipulation. In females, the disease duplicated that of (NZB x NZW)F1 females by virtue of a delayed onset and estrogen dependence. Autoantibody production, circulating Ig-bound gp 70 immune complexes, and deposition of Ig and gp 70 in the affected glomeruli were demonstrated in both males and females. The abnormally high incidence of degenerative coronary vascular disease with myocardial infarction, particularly in these F1 males, provides a useful model for the investigation of a possible immunologic component in coronary vascular disease.