Author
P Dostert
Bio: P Dostert is an academic researcher. The author has contributed to research in topics: Cysteic acid & Glycine. The author has an hindex of 1, co-authored 1 publications receiving 35 citations.
Topics: Cysteic acid, Glycine, Glutamic acid, Homocysteic acid, Glutamine
Papers
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TL;DR: Changes in aspartic acid, glutamic acid, serine, glutamine, glycine and GABA concentrations with ageing were determined in the same brain structures and were in good agreement with those previously reported.
Abstract: Concentrations of the sulfur-containing amino acids methionine, homocysteic acid, cysteic acid and taurine were measured in brain structures of young and old Wistar rats in an attempt to establish a possible link between the increase in oxidative stress with ageing and changes in tissue levels of these amino acids. Contrary to data reported by others, in all brain structures of young and old rats homocysteic acid levels could not be quantified. Compared with young rats, in old animals taurine and methionine concentrations significantly decreased in striatum and cortex; decreased taurine levels were also found in nucleus accumbens and cerebellum and lower concentrations of methionine were found in midbrain, hippocampus and pons-medulla. Cysteic acid levels either did not change or significantly increased in cortex and hippocampus. These results are discussed taking into account the biosynthesis of sulfur-containing amino acids in rat brain and the decrease in glutathione in relation to oxidative stress with ageing. Changes in aspartic acid, glutamic acid, serine, glutamine, glycine and GABA concentrations with ageing were also determined in the same brain structures and were in good agreement with those previously reported (Strolin Benedetti et al., 1990 a, b).
36 citations
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TL;DR: To prevent against cellular damages associated with oxidative stress it is important to balance the ratio of antioxidants to oxidants by supplementation or by cell induction of antioxidants.
386 citations
TL;DR: A new perspective, in which glutamate interacts with other neurotransmitters to conform the substrates of specific circuits of the brain and its relevance to aging, is included in this review.
351 citations
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104 citations
TL;DR: The results suggest that activation of GABA(A) receptors protects neurons against Abeta toxicity in AD-affected regions of the mammalian brain and that taurine should be investigated as a novel therapeutic tool in the treatment of AD and of other neurological disorders in which excitotoxicity plays a relevant role.
81 citations
TL;DR: It is shown that chronic supplementation of taurine to aged mice significantly ameliorates the age-dependent decline in memory acquisition and retention and suggests a protective role of t aurine against the normal aging process.
78 citations