P
P. Ellen Grant
Researcher at Boston Children's Hospital
Publications - 286
Citations - 11233
P. Ellen Grant is an academic researcher from Boston Children's Hospital. The author has contributed to research in topics: Medicine & Magnetic resonance imaging. The author has an hindex of 49, co-authored 237 publications receiving 9099 citations. Previous affiliations of P. Ellen Grant include Harvard University & Brigham and Women's Hospital.
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Journal ArticleDOI
Diffusion-weighted MR imaging of the brain.
TL;DR: Because stroke is common and in the differential diagnosis of most acute neurologic events, diffusion-weighted MR imaging should be considered an essential sequence, and its use in most brain MR studies is recommended.
Journal ArticleDOI
Autosomal recessive lissencephaly with cerebellar hypoplasia is associated with human RELN mutations
Susan E. Hong,Yin Yao Shugart,David T. Huang,Saad Al Shahwan,P. Ellen Grant,Jonathan O'b Hourihane,Neil D T Martin,Christopher A. Walsh +7 more
TL;DR: Although reelin was previously thought to function exclusively in brain, some humans with RELN mutations show abnormal neuromuscular connectivity and congenital lymphoedema, suggesting previously unsuspected functions for reelin in and outside of the brain.
Journal ArticleDOI
Structural brain magnetic resonance imaging of limbic and thalamic volumes in pediatric bipolar disorder
Jean A. Frazier,Sufen Chiu,Janis L. Breeze,Nikos Makris,Nicholas Lange,David N. Kennedy,Martha R. Herbert,Eileen K. Bent,Vamsi K. Koneru,Megan E. Dieterich,Steven M. Hodge,Scott L. Rauch,P. Ellen Grant,Bruce M. Cohen,Larry J. Seidman,Verne S. Caviness,Joseph Biederman +16 more
TL;DR: Findings support the hypothesis that the limbic system, in particular the hippocampus, may be involved in the pathophysiology of pediatric bipolar disorder.
Journal ArticleDOI
Patient-Customized Oligonucleotide Therapy for a Rare Genetic Disease
Jinkuk Kim,Chunguang Hu,Christelle Moufawad El Achkar,Lauren E. Black,Julie Douville,Austin Larson,Mary K. Pendergast,Sara F. Goldkind,Eunjung Lee,Eunjung Lee,Ashley Kuniholm,Aubrie Soucy,Jai Vaze,Nandkishore R. Belur,Kristina Fredriksen,Iva Stojkovska,Alla V. Tsytsykova,Myriam Armant,Renata L. DiDonato,Jaejoon Choi,Laura Cornelissen,Luis M. Pereira,Erika F. Augustine,Casie A. Genetti,Kira A. Dies,Brenda Barton,Brenda Barton,Lucinda Williams,Lucinda Williams,Benjamin D. Goodlett,Bobbie L. Riley,Amy Pasternak,Emily Berry,Kelly A. Pflock,Stephen Chu,Chantal Reed,Kimberly Tyndall,Pankaj B. Agrawal,Alan H. Beggs,P. Ellen Grant,David K. Urion,Richard O. Snyder,Susan E. Waisbren,Annapurna Poduri,Peter J. Park,Al Patterson,Alessandra Biffi,Joseph R. Mazzulli,Olaf Bodamer,Olaf Bodamer,Charles B. Berde,Timothy W. Yu,Timothy W. Yu +52 more
TL;DR: This study describes how molecular diagnosis of a rare, fatal neurodegenerative condition led to the rational design, testing, and manufacture of milasen, a splice-modulating antisense oligonucleotide drug tailored to a particular patient.
Journal ArticleDOI
Mutations in ARFGEF2 implicate vesicle trafficking in neural progenitor proliferation and migration in the human cerebral cortex
Volney L. Sheen,Vijay S. Ganesh,Meral Topçu,Guillaume Sébire,Adria Bodell,R. Sean Hill,P. Ellen Grant,Yin Yao Shugart,Jaime Imitola,Samia J. Khoury,Renzo Guerrini,Christopher A. Walsh +11 more
TL;DR: It is shown that vesicle trafficking is an important regulator of proliferation and migration during human cerebral cortical development and inhibition of BIG2 by BFA or by a dominant negative ARFGEF2 cDNA, decreases cell proliferation in vitro, suggesting a cell-autonomous regulation of neural expansion.