Author
P. H. Kelly
Bio: P. H. Kelly is an academic researcher. The author has contributed to research in topics: Olfactory tubercle & Dopamine receptor. The author has an hindex of 1, co-authored 1 publications receiving 198 citations.
Papers
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TL;DR: The results indicate that dopamine receptor distribution is well preserved in the basal ganglia during evolution, although differences among species exist in their distribution outside the basal Ganglia and their absolute amount.
Abstract: Dopamine D 1 and D 2 receptor distributions were studied in the brain of the mouse, rat, guinea pig, cat and monkey by means of in vitro quantitative autoradiography using [3H]SCH 23390 and [3H]CV 205-502 to label D 1 and D 2 subtypes respectively. The distribution of both subtypes of receptors was similar within the basal ganglia of all species investigated. The highest densities for both subtypes were found in the nucleus caudatus, putamen, nucleus accumbens, olfactory tubercle and substantia nigra. Outside of the basal ganglia, differences in the distribution of both receptors were found among the species examined in regions such as cerebellum, cortex, hippocampus, superior colliculus and olfactory bulb. In all species D 1 receptor densities were higher than those of D 2. The absolute amount of both subtypes, however, varied among species. These results indicate that dopamine receptor distribution is well preserved in the basal ganglia during evolution, although differences among species exist in their distribution outside the basal ganglia and their absolute amount.
202 citations
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TL;DR: Evidence from a series of studies with experimental animals, healthy humans, and patients with Parkinson's disease suggests the existence of an optimum DA level for cognitive function implicates the need to take into account baseline levels of DA when isolating the effects of DA.
1,383 citations
TL;DR: It is suggested that beneficial or detrimental effects of L-DOPA are observed depending on task demands and basal dopamine levels in distinct parts of the striatum, which has substantial implications for the understanding and treatment development of cognitive abnormalities in Parkinson's disease and normal health.
864 citations
TL;DR: Evidence is reviewed that highlights multiple mechanisms whereby dopamine biases memory towards events that are of motivational significance, permitting both expectations and outcomes to influence memory.
552 citations
TL;DR: Progress has been made in understanding the function of DA-containing discrete brain nuclei and the functional consequence of the DA's interaction with other neurotransmitters, and some of the latest advances in these various areas are explored.
515 citations
Journal Article•
TL;DR: Receptors for this catecholamine are of considerable interest, as they are the principal target of drugs employed in the treatment of neuropsychiatric disorders such as schizophrenia and Parkinson’s disease.
Abstract: Dopamine is a major neurotransmitter in the central nervous system. Receptors for this catecholamine are of considerable interest, as they are the principal target of drugs employed in the treatment of neuropsychiatric disorders such as schizophrenia and Parkinson’s disease. Before 1990, the
409 citations