P
P. H. Schreier
Researcher at Laboratory of Molecular Biology
Publications - 5
Citations - 9164
P. H. Schreier is an academic researcher from Laboratory of Molecular Biology. The author has contributed to research in topics: Transfer RNA & Gene. The author has an hindex of 4, co-authored 5 publications receiving 8883 citations.
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Journal ArticleDOI
Sequence and organization of the human mitochondrial genome
Stephen Anderson,Alan T. Bankier,Bart Barrell,M.H.L. de Bruijn,Alan Coulson,J. Drouin,J. Drouin,Ian C. Eperon,Donald P. Nierlich,Donald P. Nierlich,Bruce A. Roe,Bruce A. Roe,Frederick Sanger,P. H. Schreier,Andrew J.H. Smith,Rodger Staden,Ian G. Young,Ian G. Young +17 more
TL;DR: The complete sequence of the 16,569-base pair human mitochondrial genome is presented and shows extreme economy in that the genes have none or only a few noncoding bases between them, and in many cases the termination codons are not coded in the DNA but are created post-transcriptionally by polyadenylation of the mRNAs.
Journal ArticleDOI
Different pattern of codon recognition by mammalian mitochondrial tRNAs.
B. G. Barrell,Stephen Anderson,Alan T. Bankier,M.H.L. de Bruijn,Eugene G. Chen,Alan Coulson,J. Drouin,Ian C. Eperon,Donald P. Nierlich,Bruce A. Roe,Frederick Sanger,P. H. Schreier,A. Smith,Rodger Staden,Ian G. Young +14 more
TL;DR: Analysis of an almost complete mammalian mitochondrial DNA sequence has identified 23 possible tRNA genes and it is speculated here that these are sufficient to translate all the codons of the mitochondrial genetic code.
Journal ArticleDOI
A mammalian mitochondrial serine transfer RNA lacking the "dihydrouridine" loop and stem.
M.H.L. de Bruijn,P. H. Schreier,Ian C. Eperon,Bart Barrell,Ellson Y. Chen,P.W. Armstrong,J.F.H. Wong,Bruce A. Roe +7 more
TL;DR: A unique transfer RNA has been identified in human and bovine mitochondria that lacks the "dihydrouridine" loop and stem structure and can be aminoacylated with serine when purified mitochondria are incubated in a medium containing 3H-serine.
Book ChapterDOI
Sequence of Mammalian Mitochondrial DNA
Bart Barrell,Stephen Anderson,Alan T. Bankier,M.H.L. de Bruijn,Eugene G. Chen,Alan Coulson,J. Drouin,Ian C. Eperon,Donald P. Nierlich,Bruce A. Roe,Frederick Sanger,P. H. Schreier,A. Smith,Rodger Staden,Ian G. Young +14 more
TL;DR: The human mitochondrial (mt) genome consists of a closed circular duplex DNA approximately 10 x 106 daltons and has been the most intensely studied animal mt genetic system.
Different pattern ofcodonrecognition bymammalian mitochondrial tRNAs
B. G. Barrell,Stephen Anderson,Alan T. Bankier,M. H. L. Debruijn,Eugene G. Chen,Alan Coulson,J. Drouin,Ian C. Eperon,Donald P. Nierlich,Bruce A. Roe,Frederick Sanger,P. H. Schreier,A. Smith,Rodger Staden,Andi . G. Young +14 more
TL;DR: Aminimum of 32 tRNAs are needed to read all possible codons of the"universal" genetic code, but recently anumber ofinvitro experiments have indicated that thewobble hypothesis might notapply and that insomecases thethird (woble) position of thecodon hasno discriminatory function.