P R Dunbar

TL;DR: With the use of the tetrameric complexes, a significant inverse correlation was observed between HIV-specific CTL frequency and plasma RNA viral load and suggest a considerable cytopathic effect of the virus in vivo.

TL;DR: A strong and persistent CTL response in resolving acute HCV infection is demonstrated, and rationale to explore immune augmentation as a therapeutic intervention in chronic HCv infection is provided.

TL;DR: High frequencies of naive Melan-A–specific CD8+ T cells can be found in a large proportion of HLA-A*0201+ individuals, and as demonstrated for one patient followed over time, dramatic phenotype changes of circulating Melan–A-specific cells can occur in vivo.

TL;DR: These data provide the first controlled evidence of the immunogenicity of DCs in humans, and demonstrate that a single injection of mature DCs rapidly expands T-cell immunity.

TL;DR: It is shown that the activation level and the differentiation state of T-cells are closely related and may be part of the mechanism through which HIV-1-mediated immune activation exhausts the capacity of the immune system.