P
Pablo A. Valdés
Researcher at Brigham and Women's Hospital
Publications - 64
Citations - 3362
Pablo A. Valdés is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Protoporphyrin IX & Glioma. The author has an hindex of 28, co-authored 57 publications receiving 2979 citations. Previous affiliations of Pablo A. Valdés include Boston Children's Hospital & Dartmouth–Hitchcock Medical Center.
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Journal ArticleDOI
Pre-clinical whole-body fluorescence imaging: Review of instruments, methods and applications
TL;DR: This paper reviews in vivo in vivo fluorescence imaging with a particular emphasis on its potential uses and limitations, the required instrumentation, and the possible imaging geometries and applications.
Journal ArticleDOI
Quantitative fluorescence in intracranial tumor: implications for ALA-induced PpIX as an intraoperative biomarker.
Pablo A. Valdés,Frederic Leblond,Anthony Kim,Brent T. Harris,Brian C. Wilson,Xiaoyao Fan,Tor D. Tosteson,Alex Hartov,Songbai Ji,Kadir Erkmen,Kadir Erkmen,Nathan E. Simmons,Nathan E. Simmons,Keith D. Paulsen,David W. Roberts,David W. Roberts +15 more
TL;DR: This study is the first to measure quantitative ALA-induced PpIX concentrations in vivo, and the results have broad implications for guidance during resection of intracranial tumors.
Journal ArticleDOI
Coregistered fluorescence-enhanced tumor resection of malignant glioma: relationships between δ-aminolevulinic acid-induced protoporphyrin IX fluorescence, magnetic resonance imaging enhancement, and neuropathological parameters. Clinical article.
David W. Roberts,Pablo A. Valdés,Brent T. Harris,Kathryn Fontaine,Alexander Hartov,Alexander Hartov,Xiaoyao Fan,Songbai Ji,S. Scott Lollis,Brian W. Pogue,Brian W. Pogue,Frederic Leblond,Tor D. Tosteson,Tor D. Tosteson,Brian C. Wilson,Keith D. Paulsen,Keith D. Paulsen +16 more
TL;DR: The finding that preoperative MR image signatures are predictive of intraoperative PpIX fluorescence is of practical importance for identifying candidates for the procedure and provides evidence that a strong relationship exists between tumor aggressiveness and the degree of tissue fluorescence that is observable intraoperatively.
Journal ArticleDOI
Current review of in vivo GBM rodent models: emphasis on the CNS-1 tumour model.
TL;DR: This review highlights the most commonly used rodent models (U251, U86, GL261, C6, 9L and CNS-1) with a focus on the pathological and genetic similarities to the human disease.
Journal ArticleDOI
δ-aminolevulinic acid-induced protoporphyrin IX concentration correlates with histopathologic markers of malignancy in human gliomas: the need for quantitative fluorescence-guided resection to identify regions of increasing malignancy.
Pablo A. Valdés,Anthony J. Kim,Marco Brantsch,Carolyn Niu,Ziev B. Moses,Tor D. Tosteson,Brian C. Wilson,Keith D. Paulsen,David W. Roberts,Brent T. Harris +9 more
TL;DR: Data show that it is quantitatively related at the microscopic level to increasing malignancy in both low- and high-grade gliomas in both patients undergoing fluorescence-guided resection and suggests a need for improved PpIX fluorescence detection technologies to achieve better sensitivity and quantification of Ppix in tissue during surgery.