Pablo Tamayo

TL;DR: A new methodology of class discovery and clustering validation tailored to the task of analyzing gene expression data is presented and in conjunction with resampling techniques, it provides for a method to represent the consensus across multiple runs of a clustering algorithm and to assess the stability of the discovered clusters.

TL;DR: A comprehensive analysis of GPCR gene expression, copy number variation, and mutational signatures in 33 cancer types is presented and highlights the emerging role of G PCRs as part of oncocrine networks promoting tumor growth, dissemination, and immune evasion.

TL;DR: The development of a high-throughput platform for measuring radiation survival in vitro and its validation in comparison with conventional clonogenic radiation survival analysis is reported and pathways implicated in cell survival, genotoxic stress, detoxification, and innate and adaptive immunity are identified as key correlates of radiation sensitivity.

TL;DR: A mutation-specific mechanism by which oncogenic BRAF V600E "rewires" metabolic and cell signaling networks and signals through the Oct-1-HMGCL-acetoacetate axis to selectively promote BRAFV600E-dependent tumor development is revealed.

TL;DR: A framework is described for this expanded list of cancer targets, providing novel opportunities for clinical translation and indicating that the diversity of therapeutic targets engendered by non-oncogene dependencies is much larger than the list of recurrently mutated genes.