P
Pablo Tamayo
Researcher at University of California, San Diego
Publications - 185
Citations - 117545
Pablo Tamayo is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Cancer & Gene. The author has an hindex of 72, co-authored 177 publications receiving 97318 citations. Previous affiliations of Pablo Tamayo include University of California, Berkeley & Harvard University.
Papers
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Journal ArticleDOI
STRIPAK directs PP2A activity toward MAP4K4 to promote oncogenic transformation of human cells.
Jong Wook Kim,Christian Berrios,Miju Kim,Miju Kim,Amy E. Schade,Guillaume Adelmant,Huwate Yeerna,Emily Damato,Amanda Balboni Iniguez,Amanda Balboni Iniguez,Laurence Florens,Michael P. Washburn,Michael P. Washburn,Kim Stegmaier,Kim Stegmaier,Nathanael S. Gray,Pablo Tamayo,Ole Gjoerup,Jarrod A. Marto,Jarrod A. Marto,James A. DeCaprio,James A. DeCaprio,William C. Hahn,William C. Hahn,William C. Hahn +24 more
TL;DR: It is shown that ST not only displaces common PP2A B subunits but also promotes A-C subunit interactions with alternative B sub units that are components of the Striatin-interacting phosphatase and kinase (STRIPAK) complex, and that the STRIPAK complex regulatesPP2A specificity and activity.
Journal ArticleDOI
DNA methylation identifies genetically and prognostically distinct subtypes of myelodysplastic syndromes
Brian M. Reilly,Tiffany N. Tanaka,Dinh Diep,Huwate Yeerna,Pablo Tamayo,Kun Zhang,Rafael Bejar +6 more
TL;DR: Application of a nonnegative matrix factorization (NMF)-based decomposition of DNAm profiles identified 5 consensus clusters described by 5 NMF components as the most stable grouping solution, and categorized patients into 5 distinct methylation clusters, each largely defined by a single NMF component.
Journal ArticleDOI
The GenePattern Notebook Environment.
Michael Reich,Thorin Tabor,Ted Liefeld,Helga Thorvaldsdottir,Barbara Hill,Pablo Tamayo,Jill P. Mesirov,Jill P. Mesirov +7 more
TL;DR: This work has developed the GenePattern Notebook environment, to their knowledge the first system to integrate the dynamic capabilities of notebook systems with an investigator-focused, easy-to-use interface that provides access to hundreds of genomic tools without the need to write code.
Journal ArticleDOI
Cascades of transcriptional induction during human lymphocyte activation.
Leif W. Ellisen,Rachel E. Palmer,Robert G. Maki,Vivi Truong,Pablo Tamayo,Jonathan D. Oliner,Daniel A. Haber +6 more
TL;DR: Exposure profile analysis revealed the sequential induction of groups of functionally similar genes, whose temporal coregulation underscores known cellular events during T cell activation, which may prove useful for comparisons of lymphocyte responses under experimental conditions and in disease states.
Patent
Genetic markers for tumors
TL;DR: In this paper, sets of genetic markers for specific tumor classes are described, as well as methods of identifying a biological sample based on these markers, including diagnostic, prognostic, and therapeutic screening uses for these markers.