Pablo Tamayo

TL;DR: It is shown that RAF inhibitor sensitive and resistant BRAF V600 -mutant melanomas display distinct transcriptional profiles that suggest the transcriptional context in which an oncogenic event arises can have a profound impact on the establishment of oncogene-dependencies and associated drug susceptibilities.

TL;DR: The direct interaction between DDX3X and SMARCA4 in normal physiological conditions is revealed and a critical link between RNA helicases and the SWI/SNF chromatin remodeling complex in WNT/beta-catenin signaling and disease is pointed to.

TL;DR: The results provide strong empirical evidence that gene-gene correlations cannot be ignored due to the significant variance inflation they produced on the enrichment scores and should be taken into account when estimating gene set enrichment significance.

TL;DR: A parsimonious composite network with both high efficiency and absolute performance, which outperforms any single resource is created, which provides a benchmark for selection of molecular networks in human disease research.

TL;DR: In this paper, a method for grouping plural data points which are a series of gene expression values, respectively, in a computer system comprises a step for receiving the gene expression value of the data points, a step to selecting any data point exhibiting a non-prominent change in the expression values so as to leave working data points and a step by grouping the data point expressing similar patterns are grouped into clusters, respectively.