Pallu Reddanna

TL;DR: The structure-based library design approach, including the focused library design and virtual screening was used to select the 1,4-dihydropyrimidine scaffold for simultaneous inhibition of both enzyme pathways ( COX-1/COX-2 and 5-LOX) and the entire library of approximately 15,629 compounds obtained after screening for drug like properties was enumerated.

TL;DR: The relative increase in MDA is considered as the indicator of the rate of lipid peroxidation in the wake of exhaustive exercise as well as giving a scope for the involvement of GPxII associated with GST in the reduction of organic hydroperoxides.

TL;DR: The homology modeling technique has been used to construct the structure of potato 5-LOX and the results correlated well with the experimental data reported, which proved the quality of the model.

TL;DR: The development of a first cationic lipid-conjugated estrogenic derivative (ESC8) that kills breast cancer cells independent of their ER expression status is reported, which is the first example of an estrogen structure–based molecule that coinduces apoptosis and autophagy in Breast cancer cells.

TL;DR: Interestingly, all three different LTA4 methyl esters gave comparable specific activities with a given GST isozyme indicating that regiospecificity of GSTs was not the factor in determining their ability to catalyze this reaction.