Pallu Reddanna

TL;DR: In this article, a review of anti-inflammatory drugs without side effects is presented, focusing on how NSAIDs and COXIBs are associated with gastric, renal and cardiac side-effects, and should the focus be on the targets upstream or downstream of PGE2.

TL;DR: Cloned, expressed, and characterized a novel LOX isoform from the model vertebrate Danio rerio (zebrafish) that carries a Gly at this critical position, classifying this enzyme as putative arachidonic acid R-LOX, indicating that the Ala-versus-Gly concept may not always predict the reaction specificity of vertebrate LOXisoforms.

TL;DR: It has been identified that aliphatic and aromatic interactions are the most common in all the enzymes and in addition interactions unique to each one of these enzymes were identified.

TL;DR: Testing these variants facilitates tailoring of the 6-MP therapy in children with ALL and suggests that apart from the individual effect of ITPA 94 C→A, epistatic interactions between the variations of TPMT (*3C, *12) and ITPA (ex2, ex3) are associated with the6-MP toxicity.

TL;DR: The data on the preferential expression of Yc subunits in rat brains, together with the differential phenobarbital inducibility of the Ya subunit(s) in rat liver reported by Pickett et al. suggest that the Ya and Yc genes for rat GSTs are two functionally distinct gene families even though they share 68% DNA sequence homology.