Paloma Riquelme

TL;DR: Together, the results provide new insights into the tolerogenic effects of costimulatory blockade and identify DC-SIGN(+) suppressive macrophages as crucial mediators of immunological tolerance with the concomitant therapeutic implications in the clinic.

TL;DR: It is concluded that mouse M regs represent a novel, phenotypically distinct subset of suppressor macrophages, and there are solid grounds to assert a near-equivalence of mouse and human M Regs.

TL;DR: LA-ICP-MS is judged to be a suitable method for assessing expression of multiple tissue antigens in solid-phase biological specimens, such as tissue sections, cytospins, or cells grown on slides, and augur well for future development of LA-ICp-MS–based bioimaging instruments for general users.

TL;DR: Although the TAIC‐II trial did not provide conclusive evidence of a beneficial effect of preoperative TAIC treatment, the results were encouraging because they suggest that TAICs promote a state of alloantigen‐specific unresponsiveness, which might allow safe minimization of pharmacological immunosuppression.

TL;DR: It is concluded that TAIC therapy is both safe and clinically practicable; however, the TAIC‐I trial was unable to provide evidence that postoperative TAIC administration has a beneficial effect.