Palsamy Periyasamy

TL;DR: In this article, the authors present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes.

TL;DR: This review highlights recent advances in the field on the role of ER stress and autophagy in AD, prion diseases, PD, ALS and HAND with the involvement of key signaling pathways in these processes and implications for future development of therapeutic strategies.

TL;DR: A novel role of Tat is demonstrated in priming and activating NLR family pyrin domain containing 3 (NLRP3) inflammasomes in microglial cells and in HIV-Tg rats administered lipopolysaccharide, which suggests NLRP3 can be envisioned as a therapeutic target for ameliorating Tat-mediated neuroinflammation.

TL;DR: It is demonstrated that cocaine exposure induced autophagy in both BV-2 and primary rat microglial cells as demonstrated by a dose- and time-dependent induction of autophile-signature proteins such as BECN1/Beclin 1, ATG5, and MAP1LC3B.

TL;DR: The overall view of ER stress, increases in Ca2+ levels, protein cleavage, and loss of the well‐established stress protection in somatic lens cells are summarized.