P
Pamela L. Schwartzberg
Researcher at National Institutes of Health
Publications - 174
Citations - 22341
Pamela L. Schwartzberg is an academic researcher from National Institutes of Health. The author has contributed to research in topics: T cell & Cellular differentiation. The author has an hindex of 74, co-authored 159 publications receiving 20143 citations. Previous affiliations of Pamela L. Schwartzberg include Uniformed Services University of the Health Sciences & Scripps Research Institute.
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Journal ArticleDOI
A Critical Role for IL-21 in Regulating Immunoglobulin Production
Katsutoshi Ozaki,Rosanne Spolski,Carl G. Feng,Chen-Feng Qi,Jun Cheng,Alan Sher,Herbert C. Morse,Chengyu Liu,Pamela L. Schwartzberg,Warren J. Leonard +9 more
TL;DR: It is demonstrated that, although mice deficient in the receptor for IL-21 (IL-21R) have normal lymphoid development, after immunization, these animals have higher production of the immunoglobulin IgE, but lower IgG1, than wild-type animals, suggesting that these γc-dependent cytokines may be those whose inactivation is primarily responsible for the B cell defect in humans with XSCID.
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PKC-θ is required for TCR-induced NF-κB activation in mature but not immature T lymphocytes.
Zuoming Sun,Christopher Arendt,Wilfried Ellmeier,Wilfried Ellmeier,Edward M. Schaeffer,Edward M. Schaeffer,Mary Jean Sunshine,Mary Jean Sunshine,Leena Gandhi,Justin P. Annes,Daniela Petrzilka,Daniela Petrzilka,Abraham Kupfer,Pamela L. Schwartzberg,Dan R. Littman,Dan R. Littman +15 more
TL;DR: The results indicate that PKC-θ functions in a unique pathway that links the TCR signalling complex to the activation of NF-κB in mature T lymphocytes, and induction of JNK was normal in T cells from mutant mice.
Journal ArticleDOI
Selective requirement for Src kinases during VEGF-induced angiogenesis and vascular permeability.
TL;DR: Although mice lacking individual Src family kinases (SFKs) showed normal angiogenesis, mice deficient in pp60c-src or pp62c-yes showed no VEGF-induced vascular permeability (VP), yet fyn-/- mice displayed normal VP.
Journal ArticleDOI
A Mosaic Activating Mutation in AKT1 Associated with the Proteus Syndrome
Marjorie J. Lindhurst,Julie C Sapp,Jamie K. Teer,Jennifer J. Johnston,Erin M Finn,Kathryn F. Peters,Joyce T. Turner,Jennifer L. Cannons,David P. Bick,Laurel C Blakemore,Catherine Blumhorst,Knut Brockmann,Peter Calder,Natasha Cherman,Matthew A. Deardorff,David B. Everman,Gretchen Golas,Robert M. Greenstein,B. Maya Kato,Kim M. Keppler-Noreuil,Sergei A. Kuznetsov,Richard T. Miyamoto,Kurt D. Newman,David Ng,Kevin O'Brien,Steven S. Rothenberg,Douglas J. Schwartzentruber,Virender Singhal,Roberto Tirabosco,Joseph Upton,Shlomo Wientroub,Elaine H. Zackai,Kimberly Hoag,Tracey Whitewood-Neal,Pamela Gehron Robey,Pamela L. Schwartzberg,Thomas N. Darling,Laura L. Tosi,James C. Mullikin,Leslie G. Biesecker +39 more
TL;DR: In this article, exome sequencing of DNA from biopsy samples obtained from patients with the Proteus syndrome and compared the resultant DNA sequences with those of unaffected tissues obtained from the same patients were performed.
Journal ArticleDOI
Defining ‘T cell exhaustion’
Christian U. Blank,W. Nicholas Haining,Werner Held,Patrick G. Hogan,Patrick G. Hogan,Axel Kallies,Enrico Lugli,Rachel C. Lynn,Mary Philip,Anjana Rao,Anjana Rao,Nicholas P. Restifo,Andrea Schietinger,Ton N. Schumacher,Pamela L. Schwartzberg,Arlene H. Sharpe,Daniel E. Speiser,E. John Wherry,Benjamin Youngblood,Dietmar Zehn +19 more
TL;DR: In this Viewpoint article, 18 experts in the field tell us what exhaustion means to them, ranging from complete lack of effector function to altered functionality to prevent immunopathology, with potential differences between cancer and chronic infection.