Author
Pamela Robles Martinez
Bio: Pamela Robles Martinez is an academic researcher from University College London. The author has contributed to research in topics: Self-healing hydrogels & Risk analysis (engineering). The author has an hindex of 4, co-authored 4 publications receiving 606 citations.
Papers
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TL;DR: This work has demonstrated the potential of 3DP to manufacture tablet shapes of different geometries, many of which would be challenging to manufacture by powder compaction.
494 citations
TL;DR: 3D printing was used to prepare ibuprofen-loaded hydrogels of cross-linked polyethylene glycol diacrylate, and Dissolution profiles showed that drug release rates were dependent on water content, with higher water content hydrogel releasing drug faster.
171 citations
TL;DR: 3D printing is therefore a suitable manufacturing method for personalized dosage forms and dissolution performance can be maintained if the SA/V ratio is constant or that dissolution performance of printlets can be fine-tuned by varying SA-V ratio.
Abstract: Additive manufacturing (3D printing) permits the fabrication of tablets in shapes unattainable by powder compaction, and so the effects of geometry on drug release behavior is easily assessed. Here, tablets (printlets) comprising of paracetamol dispersed in polyethylene glycol were printed using stereolithographic 3D printing. A number of geometric shapes were produced (cube, disc, pyramid, sphere and torus) with either constant surface area (SA) or constant surface area/volume ratio (SA/V). Dissolution testing showed that printlets with constant SA/V ratio released drug at the same rate, while those with constant SA released drug at different rates. A series of tori with increasing SA/V ratio (from 0.5 to 2.4) were printed, and it was found that dissolution rate increased as the SA/V ratio increased. The data show that printlets can be fabricated in multiple shapes and that dissolution performance can be maintained if the SA/V ratio is constant or that dissolution performance of printlets can be fine-tuned by varying SA/V ratio. The results suggest that 3D printing is therefore a suitable manufacturing method for personalized dosage forms.
127 citations
01 Jan 2018
TL;DR: This chapter presents an overview of the fundamental science behind the photopolymerisation process and the SLA 3DP technologies available, and a variety of its biomedical uses are presented.
Abstract: Stereolithography (SLA) is an additive manufacturing technique that uses light as the source of energy. SLA 3D printing (3DP) was the first rapid prototyping method developed and perhaps the most popular due to its superior resolution and accuracy. Due to its versatility, SLA has been widely studied for its use in tissue engineering or in dentistry. In the pharmacoprinting field, SLA offers a great potential for fabricating complex drug delivery systems as well as approaching the need to manufacture personalised medicine. Despite this, research in the use of SLA 3DP in the pharmaceutical area is still limited. This chapter presents an overview of the fundamental science behind the photopolymerisation process and the SLA 3DP technologies available. A variety of its biomedical uses are presented. The multiple potential pharmaceutical applications and recent advances are reviewed, along with the advantages and limitations of this rapid prototyping technique for the manufacture of modern medicines.
32 citations
TL;DR: In this paper , a 3D IUS containing progesterone using vat photopolymerisation (VPP) technique was successfully printed and showed a slow release in phosphate buffer (pH 7.4).
Abstract: Three-dimensional printing (3DP)provides the opportunity to personalise different dosage forms and therapeutic regimenwhere conventional manufacturing processes might not be applicable. Limitedwork has been done to investigate using 3DP for personalising hormonal intrauterinesystems (IUSs). The aim of this work was to prepare 3DP IUS containing progesteroneusing vat photopolymerisation (VPP) technique. The device was successfullyprinted and showed a slow release in phosphate buffer (pH 7.4). VPP has theadvantages of better printing resolution producing smoother surfaces, and theelimination of the pre-printing process of hot melt extrusion (HME) needed for fuseddeposition modelling (FDM) method. To the author’s knowledge, this is the firstreport of using VPP for printing hormone-loaded IUSs.@font-face{font-family:"Cambria Math";panose-1:2 4 5 3 5 4 6 3 2 4;mso-font-charset:0;mso-generic-font-family:roman;mso-font-pitch:variable;mso-font-signature:-536870145 1107305727 0 0 415 0;}@font-face{font-family:Calibri;panose-1:2 15 5 2 2 2 4 3 2 4;mso-font-charset:0;mso-generic-font-family:swiss;mso-font-pitch:variable;mso-font-signature:-469750017 -1073732485 9 0 511 0;}p.MsoNormal, li.MsoNormal, div.MsoNormal{mso-style-unhide:no;mso-style-qformat:yes;mso-style-parent:"";margin-top:0cm;margin-right:0cm;margin-bottom:10.0pt;margin-left:0cm;line-height:115%;mso-pagination:widow-orphan;font-size:11.0pt;font-family:"Arial",sans-serif;mso-fareast-font-family:Calibri;mso-fareast-language:EN-US;}.MsoChpDefault{mso-style-type:export-only;mso-default-props:yes;font-size:10.0pt;mso-ansi-font-size:10.0pt;mso-bidi-font-size:10.0pt;font-family:"Arial",sans-serif;mso-ascii-font-family:Arial;mso-fareast-font-family:Calibri;mso-hansi-font-family:Arial;mso-bidi-font-family:Arial;}div.WordSection1{page:WordSection1;}
1 citations
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TL;DR: A comprehensive review of the main 3D printing methods, materials and their development in trending applications was carried out in this paper, where the revolutionary applications of AM in biomedical, aerospace, buildings and protective structures were discussed.
Abstract: Freedom of design, mass customisation, waste minimisation and the ability to manufacture complex structures, as well as fast prototyping, are the main benefits of additive manufacturing (AM) or 3D printing. A comprehensive review of the main 3D printing methods, materials and their development in trending applications was carried out. In particular, the revolutionary applications of AM in biomedical, aerospace, buildings and protective structures were discussed. The current state of materials development, including metal alloys, polymer composites, ceramics and concrete, was presented. In addition, this paper discussed the main processing challenges with void formation, anisotropic behaviour, the limitation of computer design and layer-by-layer appearance. Overall, this paper gives an overview of 3D printing, including a survey on its benefits and drawbacks as a benchmark for future research and development.
4,159 citations
TL;DR: Polymers are by far the most utilized class of materials for AM and their design, additives, and processing parameters as they relate to enhancing build speed and improving accuracy, functionality, surface finish, stability, mechanical properties, and porosity are addressed.
Abstract: Additive manufacturing (AM) alias 3D printing translates computer-aided design (CAD) virtual 3D models into physical objects. By digital slicing of CAD, 3D scan, or tomography data, AM builds objects layer by layer without the need for molds or machining. AM enables decentralized fabrication of customized objects on demand by exploiting digital information storage and retrieval via the Internet. The ongoing transition from rapid prototyping to rapid manufacturing prompts new challenges for mechanical engineers and materials scientists alike. Because polymers are by far the most utilized class of materials for AM, this Review focuses on polymer processing and the development of polymers and advanced polymer systems specifically for AM. AM techniques covered include vat photopolymerization (stereolithography), powder bed fusion (SLS), material and binder jetting (inkjet and aerosol 3D printing), sheet lamination (LOM), extrusion (FDM, 3D dispensing, 3D fiber deposition, and 3D plotting), and 3D bioprinting....
2,136 citations
TL;DR: It is believed that the recent approval of a 3D printed drug product will stimulate continual innovation in pharmaceutical manufacturing technology and highlight how product and process understanding can facilitate the development of a control strategy for different 3D printing methods.
544 citations
TL;DR: SLA 3DP technology allows the manufacture of drug loaded tablets with specific extended-release profiles and could become a manufacturing technology for the elaboration of oral dosage forms, for industrial production or even for personalised dose.
498 citations
TL;DR: This paper aims to review the processes that can be used in pharmaceutics, including the parameters to be controlled, to give an overview on the pragmatic tools, which can beused for designing customized drug delivery systems using 3D printing.
479 citations