Pamela Troisch

TL;DR: It is demonstrated that specific microRNA species, such as mir-122 and mir-192, both are enriched in the liver tissue and exhibit dose- and exposure duration-dependent changes in the plasma that parallel serum aminotransferase levels and the histopathology of liver degeneration, but their changes can be detected significantly earlier.

TL;DR: Huang et al. as discussed by the authors performed a deep multi-omic, longitudinal investigation of 309 COVID-19 patients from initial diagnosis to convalescence (2-3 months later), integrated with clinical data and patient-reported symptoms.

TL;DR: It is suggested that moderate disease may provide the most effective setting for therapeutic intervention, at which point elevated inflammatory signaling is accompanied by the loss of specific classes of metabolites and metabolic processes at moderate disease.

TL;DR: RNA rearrangement is identified here as a key event in memory T cell differentiation by analysis of a mouse mutation that altered the proportions of naive and memory T cells and crippled the process of Ptprc exon silencing needed to generate CD45RO inMemory T cells.

TL;DR: Genes differentially expressed in cancer are potential biomarkers for cancer detection, and those differentially expression between G3 and G4 are possible biomarker for disease stratification given that G4 cancer is associated with poor outcomes.