Author
Panagiota Karagianni
Bio: Panagiota Karagianni is an academic researcher from National and Kapodistrian University of Athens. The author has contributed to research in topics: Epigenetics & DNA methylation. The author has an hindex of 6, co-authored 13 publications receiving 249 citations.
Papers
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TL;DR: High-dimensional single-cell protein and RNA expression data is integrated to identify distinct markers to delineate monocytes from conventional DC2 (cDC2s), further unravel the heterogeneity of DC subpopulations in health and disease and may pave the way for the identification of specific DC subset-targeting therapies.
283 citations
TL;DR: Epigenetic changes, including covalent modifications of the DNA and histones, are critical signaling mediators between the genome and the environment, and thus potent regulators of cellular functions and have the potential to serve as biomarkers for disease status, prognosis, and response to treatment.
41 citations
TL;DR: In this paper, the authors explore the inclusion discourse in Greece at a period characterized by change in policy and practice and discuss critically the distance between the strong voices and weak practices that characterizes the Greek inclusive discourse.
Abstract: This paper explores the inclusive discourse in Greece at a period characterized by change in policy and practice. The aim is to discuss critically the distance between the strong voices and weak practices that characterizes the Greek inclusive discourse. The first part focuses on disability and presents the ways that a ‘common sense’ understanding of disability is constructed in the public domain resulting in the de‐politicization of the inclusive discourse. The second part focuses on inclusive education, discussing the contradiction between the rhetoric of inclusive education and the reality of the expansion of special provision for an increasing number of students. It is argued that the fragmentation of the inclusive discourse and the emphasis on common sense assumptions about human and social rights reduce policies about inclusive education to an add‐on, peripheral element of the proposed educational reforms.
33 citations
TL;DR: The 1000 Genomes Project provides a database of genomic variants from whole genome sequencing of 2504 individuals across five continental superpopulations that can enrich the background knowledge of worldwide blood group variant geographic distribution and identify novel variants of potential clinical significance.
18 citations
TL;DR: DNA methylation levels of the IL8 and F3 genes between healthy donors (HDs) and APS patients, using whole blood as a source support that epigenetic alterations could be implicated in the pathophysiology of APS and prompt further investigation of their potential diagnostic or therapeutic utility.
13 citations
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TL;DR: A review of the recent progress in cancer immunotherapy is outlined, particularly by focusing on landmark studies and the recent single-cell characterization of tumor-associated immune cells, and the phenotypic diversities of intratumoral immune cells and their connections with cancer Immunotherapy are summarized.
Abstract: Immunotherapy has revolutionized cancer treatment and rejuvenated the field of tumor immunology Several types of immunotherapy, including adoptive cell transfer (ACT) and immune checkpoint inhibitors (ICIs), have obtained durable clinical responses, but their efficacies vary, and only subsets of cancer patients can benefit from them Immune infiltrates in the tumor microenvironment (TME) have been shown to play a key role in tumor development and will affect the clinical outcomes of cancer patients Comprehensive profiling of tumor-infiltrating immune cells would shed light on the mechanisms of cancer–immune evasion, thus providing opportunities for the development of novel therapeutic strategies However, the highly heterogeneous and dynamic nature of the TME impedes the precise dissection of intratumoral immune cells With recent advances in single-cell technologies such as single-cell RNA sequencing (scRNA-seq) and mass cytometry, systematic interrogation of the TME is feasible and will provide insights into the functional diversities of tumor-infiltrating immune cells In this review, we outline the recent progress in cancer immunotherapy, particularly by focusing on landmark studies and the recent single-cell characterization of tumor-associated immune cells, and we summarize the phenotypic diversities of intratumoral immune cells and their connections with cancer immunotherapy We believe such a review could strengthen our understanding of the progress in cancer immunotherapy, facilitate the elucidation of immune cell modulation in tumor progression, and thus guide the development of novel immunotherapies for cancer treatment
737 citations
TL;DR: These guidelines are a consensus work of a considerable number of members of the immunology and flow cytometry community providing the theory and key practical aspects offlow cytometry enabling immunologists to avoid the common errors that often undermine immunological data.
Abstract: These guidelines are a consensus work of a considerable number of members of the immunology and flow cytometry community. They provide the theory and key practical aspects of flow cytometry enabling immunologists to avoid the common errors that often undermine immunological data. Notably, there are comprehensive sections of all major immune cell types with helpful Tables detailing phenotypes in murine and human cells. The latest flow cytometry techniques and applications are also described, featuring examples of the data that can be generated and, importantly, how the data can be analysed. Furthermore, there are sections detailing tips, tricks and pitfalls to avoid, all written and peer-reviewed by leading experts in the field, making this an essential research companion.
698 citations
TL;DR: This comprehensive analysis of key myeloid subsets in human and mouse identifies critical cellular interactions regulating tumor immunity and defines mechanisms underlying myeloids-targeted immunotherapies currently undergoing clinical testing.
549 citations
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TL;DR: Blood Groups in Man, by Dr. R. R Race and Dr. Ruth Sanger, 1950 is published.
Abstract: Blood Groups in Man By Dr. R. R. Race and Dr. Ruth Sanger. Pp. xv + 290. (Oxford: Blackwell Scientific Publications, Ltd., 1950.) 30s. net.
534 citations
TL;DR: A pan-cancer analysis of single myeloid cells from 210 patients across 15 human cancer types identified distinct features of TIMs across cancer types and suggested future avenues for rational, targeted immunotherapies.
374 citations