P
Pankaj Baral
Researcher at Harvard University
Publications - 36
Citations - 1991
Pankaj Baral is an academic researcher from Harvard University. The author has contributed to research in topics: Nociceptor & Signal transduction. The author has an hindex of 15, co-authored 32 publications receiving 1336 citations. Previous affiliations of Pankaj Baral include Louisiana State University & Tribhuvan University.
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Journal ArticleDOI
The neuropeptide NMU amplifies ILC2-driven allergic lung inflammation
Antonia Wallrapp,Samantha J. Riesenfeld,Patrick R. Burkett,Raja-Elie E. Abdulnour,Jackson Nyman,Danielle Dionne,Matan Hofree,Michael S. Cuoco,Christopher Rodman,Daneyal Farouq,Brian J. Haas,Timothy L. Tickle,John J. Trombetta,Pankaj Baral,Christoph S.N. Klose,Tanel Mahlakõiv,David Artis,Orit Rozenblatt-Rosen,Isaac M. Chiu,Bruce D. Levy,Monika S. Kowalczyk,Aviv Regev,Aviv Regev,Vijay K. Kuchroo,Vijay K. Kuchroo +24 more
TL;DR: In this paper, the authors profiled mouse lung-resident ILCs using single-cell RNA sequencing at steady state and after in vivo stimulation with the alarmin cytokines IL-25 and IL-33.
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Nociceptor sensory neurons suppress neutrophil and γδ T cell responses in bacterial lung infections and lethal pneumonia
Pankaj Baral,Benjamin D. Umans,Lu Li,Antonia Wallrapp,Meghna Bist,Talia Kirschbaum,Yibing Wei,Yan Zhou,Vijay K. Kuchroo,Patrick R. Burkett,Bryan G. Yipp,Stephen D. Liberles,Isaac M. Chiu +12 more
TL;DR: It is found that TRPV1+ nociceptors suppressed protective immunity against lethal Staphylococcus aureus pneumonia and targeting neuroimmunological signaling increased survival, cytokine induction, and lung bacterial clearance.
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Pain and immunity: implications for host defence
TL;DR: The role of nociceptor interactions with the immune system in pain and infection is discussed and how understanding these pathways could produce new approaches to treat infectious diseases and chronic pain is discussed.
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Gut-Innervating Nociceptor Neurons Regulate Peyer’s Patch Microfold Cells and SFB Levels to Mediate Salmonella Host Defense
Nicole Y. Lai,Melissa A. Musser,Melissa A. Musser,Felipe A. Pinho-Ribeiro,Pankaj Baral,Amanda Jacobson,Pingchuan Ma,David E. Potts,Zuojia Chen,Zuojia Chen,Donggi Paik,Salima Soualhi,Yiqing Yan,Aditya Misra,Kaitlin Goldstein,Valentina N. Lagomarsino,Anja Nordstrom,Kisha N. Sivanathan,Antonia Wallrapp,Vijay K. Kuchroo,Roni Nowarski,Michael N. Starnbach,Hailian Shi,Hailian Shi,Neeraj K. Surana,Dingding An,Chuan Wu,Chuan Wu,Jun R. Huh,Meenakshi Rao,Isaac M. Chiu +30 more
TL;DR: It is found that nociceptor neurons critically mediate host defense against the bacterial pathogen Salmonella enterica serovar Typhimurium (STm), and a major role is revealed in sensing and defending against enteric pathogens.
Journal ArticleDOI
High prevalence of multidrug resistance in bacterial uropathogens from Kathmandu, Nepal
Pankaj Baral,Pankaj Baral,Sanjiv Neupane,Bishnu P. Marasini,Kashi Ram Ghimire,Binod Lekhak,Basudha Shrestha +6 more
TL;DR: The high prevalence of multidrug resistance in bacterial uropathogens was observed, and resistance patterns were alarmingly higher for amoxycillin, co-trimoxazole, flouroquinolones and third-generation cephalosporins, which necessitate the re-evaluation of first and second line therapies for UTI.