P
Paola Lucarelli
Researcher at National Research Council
Publications - 63
Citations - 2111
Paola Lucarelli is an academic researcher from National Research Council. The author has contributed to research in topics: Population & Allele. The author has an hindex of 15, co-authored 63 publications receiving 2059 citations. Previous affiliations of Paola Lucarelli include University of Naples Federico II & University of Rome Tor Vergata.
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Journal ArticleDOI
A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes
Nunzio Bottini,Lucia Musumeci,Andres Alonso,Souad Rahmouni,Konstantina Nika,Masoud Rostamkhani,James P. MacMurray,Gian Franco Meloni,Paola Lucarelli,Maurizio Pellecchia,George S. Eisenbarth,David E. Comings,Tomas Mustelin +12 more
TL;DR: A single-nucleotide polymorphism in the gene (PTPN22) encoding the lymphoid protein tyrosine phosphatase (LYP), a suppressor of T-cell activation, is associated with type 1 diabetes mellitus (T1D).
Journal ArticleDOI
Autism: evidence of association with adenosine deaminase genetic polymorphism.
Nunzio Bottini,Danila De Luca,Patrizia Saccucci,Agata Fiumara,Maurizio Elia,Maria Cristina Porfirio,Paola Lucarelli,Paolo Curatolo +7 more
TL;DR: It is suggested that this putative genotype-dependent reduction in ADA activity may be a risk factor for the development of autism.
Journal ArticleDOI
Favism: Association with Erythrocyte Acid Phosphatase Phenotype
TL;DR: The frequency of carriers of the Paand Pc alleles of the gene for acid phosphatase in the erythrocyte is significantly higher in male subjects deficient in glucose-6-phosphate dehydrogenase and having hemolytic clinical favism than it is in the general population.
Journal ArticleDOI
Genetic differentiation among Sardinian villages.
P. L. Workman,Paola Lucarelli,R. Agostino,R. Scarabino,Renato Scacchi,E. Carapella,R. Palmarino,E. Bottini +7 more
TL;DR: Isolation due in part to cultural factors, genetic drift, and special local or regional patterns of villages associations appear to be involved in the pattern of genetic variation.
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Both maternal and foetal genetic factors contribute to macrosomia of diabetic pregnancy.
TL;DR: The study of 230 diabetic mothers along with their newborn babies has shown that foetal macrosomia is associated with two specific genomic sites: phosphoglucomutase locus 1-Rhesus blood group (Rh) linkage group and HindIII restriction fragment length polymorphism (RFLP) linked to insulin-like growth factor 1 (IGF1) (chromosome 12).