Paola Naldi

TL;DR: In this article, a collaborative GWAS involving 9,772 cases of European descent collected by 23 research groups working in 15 different countries, they have replicated almost all of the previously suggested associations and identified at least a further 29 novel susceptibility loci.

TL;DR: A protein-interaction-network-based pathway analysis (PINBPA) on two large genetic MS studies finds that products of genome-wide significantly associated genes are more likely to interact physically and belong to the same or related pathways.

TL;DR: In the right-handers, paired TMS studies showed a functional asymmetry of the motor cortex between the dominant and the non-dominant hand, while the left- handers did not show this lateralization.

TL;DR: Bayesian logic and empirical data suggested that association studies in complex disease should involve at least 2000 cases and 2000 controls, at which level they predicted that p values of less than 5×10 −7 would more commonly signify true positives than false positives.

TL;DR: The association with HLA-DRB1 alleles was tested in 609 Continental Italian MS patients and 836 controls and did not detect an influence of the DR phenotype on disease course, age at onset/ diagnosis, gender or familiarity.