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Parashar Dhapola
Researcher at Lund University
Publications - 26
Citations - 294
Parashar Dhapola is an academic researcher from Lund University. The author has contributed to research in topics: Haematopoiesis & Progenitor cell. The author has an hindex of 7, co-authored 17 publications receiving 200 citations. Previous affiliations of Parashar Dhapola include Council of Scientific and Industrial Research & Institute of Genomics and Integrative Biology.
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Journal ArticleDOI
QuadBase2: web server for multiplexed guanine quadruplex mining and visualization.
TL;DR: TetraplexFinder, the module for mining PG4 motifs in user-provided sequences is now capable of handling up to 20 MB of data, and QuadBase2 is a comprehensive PG 4 motif mining tool that further expands the configurations and algorithms for miningPG4 motifing in a user-friendly way.
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Epigenetic suppression of human telomerase (hTERT) is mediated by the metastasis suppressor NME2 in a G-quadruplex-dependent fashion.
Dhurjhoti Saha,Ankita Singh,Tabish Hussain,Vivek Srivastava,Suman Sengupta,Anirban Kar,Parashar Dhapola,Vishnu Dhople,Ramesh Ummanni,Shantanu Chowdhury +9 more
TL;DR: A mechanism of hTERT epigenetic control involving a G-quadruplex promoter motif, which potentially can be targeted by tailored small molecules is supported, which indicates that loss of NME2 results in up-regulated h TERT expression.
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Transcription regulation of CDKN1A (p21/CIP1/WAF1) by TRF2 is epigenetically controlled through the REST repressor complex
Tabish Hussain,Dhurjhoti Saha,Gunjan Purohit,Anirban Kar,Anand Kishore Mukherjee,Shalu Sharma,Suman Sengupta,Parashar Dhapola,Basudeb Maji,Basudeb Maji,Sreekanth Vedagopuram,Nobuko T. Horikoshi,Nobuo Horikoshi,Raj K. Pandita,Santanu Bhattacharya,Santanu Bhattacharya,Avinash Bajaj,Jean François Riou,Tej K. Pandita,Shantanu Chowdhury +19 more
TL;DR: Physiologically, TRF2-mediated p21 repression attenuated drug-induced activation of cellular DNA damage response by evading G2/M arrest in cancer cells and mutational analysis reveals for the first time role of TRF 2 in REST- repressor complex mediated transcription repression.
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Novel internal regulators and candidate miRNAs within miR-379/miR-656 miRNA cluster can alter cellular phenotype of human glioblastoma
Subhashree Nayak,Meghali Aich,Anupam Kumar,Suman Sengupta,Prajakta Bajad,Parashar Dhapola,Deepanjan Paul,Deepanjan Paul,Kiran Narta,Kiran Narta,Suvendu Purkrait,Bharati Mehani,Bharati Mehani,Ashish Suri,Debojyoti Chakraborty,Debojyoti Chakraborty,Arijit Mukhopadhyay,Arijit Mukhopadhyay,Arijit Mukhopadhyay,Chitra Sarkar +19 more
TL;DR: The results emphasize the tumor suppressive role of C14MC in diffuse gliomas, and identifies two specific miRNAs with potential therapeutic value and towards better disease management and therapy.
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ATF3 negatively regulates cellular antiviral signaling and autophagy in the absence of type I interferons.
Vikas Sood,Kiran Bala Sharma,Vishal Gupta,Dhurjhoti Saha,Parashar Dhapola,Parashar Dhapola,Manish Sharma,Utsav Sen,Shigetaka Kitajima,Shantanu Chowdhury,Shantanu Chowdhury,Manjula Kalia,Sudhanshu Vrati +12 more
TL;DR: It is shown that ATF3 is induced following Japanese encephalitis virus (JEV) infection, and regulates cellular antiviral and autophagy pathways in the absence of type I interferons in mouse neuronal cells.