Paresh U. Patoliya

Bio: Paresh U. Patoliya is an academic researcher from Central Salt and Marine Chemicals Research Institute. The author has contributed to research in topics: Bromide & Isoindoles. The author has an hindex of 3, co-authored 8 publications receiving 133 citations. Previous affiliations of Paresh U. Patoliya include Council of Scientific and Industrial Research.

An efficient method for the synthesis of 2,3-dihydro-1H-isoindoles

Abstract: The synthesis of N-substituted 2,3-dihydro-1H-isoindoles from α,α'-dibromo-o-xylene and various primary amines in basic medium under ambient conditions is described. Especially the selection of 1,4-dioxane as solvent and sodium hydroxide as suitable base to maintain the homogeneity of the medium are key steps to promote the reaction efficiently. Primary alkyl amines react faster as compared to their aromatic analogues under the conditions studied. Irrespective of the starting amine used, all the reactions proceed smoothly and provide 2,3-dihydro-1H-isoindoles derivatives in excellent yields compared to hitherto known methods.

An improved process for the preparation of para-nitrobenzyl bromide

Abstract: An improved process for the preparation of p-nitrobenzyl bromide from p-nitrotoluene is disclosed wherein large excess of the reactant in carbon tetrachloride is treated with 2:1 bromide-bromate reagent and the product is isolated efficiently and with high purity through selective cold crystallization from reaction mass so as to allow the mother liquor to be recycled in a subsequent batch without any further work up. The cycles are continued so long as product of desired quality is obtained in adequate yield. Thereafter, the solvent and p-nitrotoluene are recovered from the mother liquor and the residue is treated with sodium borohydride to convert impurities back into reactant or product which is then recycled in the process thereby circumventing the problem of waste disposal and simultaneously yielding the desired product with >95 % yield with respect to p-nitrotoluene and >88 % bromine atom efficiency.

An efficient method for the synthesis of 2,3-dihydro-1 H -isoindoles

Abstract: The synthesis of N-substituted 2,3-dihydro-1H-isoindoles from α,α′-dibromo-o-xylene and various primary amines in basic medium under ambient conditions is described. Especially the selection of 1,4-dioxane as solvent and sodium hydroxide as suitable base to maintain the homogeneity of the medium are key steps to promote the reaction efficiently. Primary alkyl amines react faster as compared to their aromatic analogues under the conditions studied. Irrespective of the starting amine used, all the reactions proceed smoothly and provide 2,3-dihydro-1H-isoindoles derivatives in excellent yields compared to hitherto known methods.

Use of Bromine and Bromo-Organic Compounds in Organic Synthesis

Abstract: Bromination is one of the most important transformations in organic synthesis and can be carried out using bromine and many other bromo compounds. Use of molecular bromine in organic synthesis is well-known. However, due to the hazardous nature of bromine, enormous growth has been witnessed in the past several decades for the development of solid bromine carriers. This review outlines the use of bromine and different bromo-organic compounds in organic synthesis. The applications of bromine, a total of 107 bromo-organic compounds, 11 other brominating agents, and a few natural bromine sources were incorporated. The scope of these reagents for various organic transformations such as bromination, cohalogenation, oxidation, cyclization, ring-opening reactions, substitution, rearrangement, hydrolysis, catalysis, etc. has been described briefly to highlight important aspects of the bromo-organic compounds in organic synthesis.

The chemistry of isoindole natural products

Abstract: This review highlights the chemical and biological aspects of natural products containing an oxidized or reduced isoindole skeleton. This motif is found in its intact or modified form in indolocarbazoles, macrocyclic polyketides (cytochalasan alkaloids), the aporhoeadane alkaloids, meroterpenoids from Stachybotrys species and anthraquinone-type alkaloids. Concerning their biological activity, molecular structure and synthesis, we have limited this review to the most inspiring examples. Within different congeners, we have selected a few members and discussed the synthetic routes in more detail. The putative biosynthetic pathways of the presented isoindole alkaloids are described as well.

Copper‐Catalyzed Aerobic Oxidation of Amines to Imines under Neat Conditions with Low Catalyst Loading

Abstract: The copper (I)-catalyzed direct synthesis of imines from amines under mild aerobic conditions is described. The method is applicable for the synthesis of various imines from corresponding amines such as benzylic, aliphatic, cyclic secondary, heteroaromatic species and the oxidative condensation of benzylamines with anilines extends the scope of the CuCl catalytic system. Noteworthy, solvent-free procedure, air as a benign oxidant, and the cheap and easy availability of the catalyst are the vital advantages of the method.

Utilization of methylarenes as versatile building blocks in organic synthesis.

Abstract: The development of practical and efficient methods for C–C and C–X bond formation has attracted a great deal of current attention with the advent of C–H functionalization reactions. Hydrocarbons are perhaps the most inexpensive and readily available materials, and utilisation of such materials for the synthesis of essential chemicals is virtually and economically pragmatic. The means to utilize easily accessible hydrocarbons not only represents a useful, potent and straightforward alternative, but also constitutes an excellent opportunity to improve our chemical knowledge about a relatively unexplored domain. Early examples using alkylarenes are generally limited to their conversion to aldehydes, carboxylic acids, and nitriles. This review intends to focus on the latest developments adopting modern strategies for sp3 C–H functionalization of methylarenes to achieve a diverse range of important organic compounds.