Author
Parikshit S. Sharma
Other affiliations: Geisinger Health System, Virginia Commonwealth University, Rush University ...read more
Bio: Parikshit S. Sharma is an academic researcher from Rush University Medical Center. The author has contributed to research in topics: Medicine & Cardiac resynchronization therapy. The author has an hindex of 22, co-authored 93 publications receiving 2013 citations. Previous affiliations of Parikshit S. Sharma include Geisinger Health System & Virginia Commonwealth University.
Papers
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TL;DR: Permanent HBP without a mapping catheter or a backup right ventricular lead was successfully achieved in 80% of patients and clinical outcomes were better in the HBP group than in the RVP group.
307 citations
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TL;DR: Permanent His-bundle pacing may be considered as a rescue strategy for failed BVP and may be a reasonable primary alternative to BVP for CRT.
296 citations
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TL;DR: In patients undergoing pacemaker implantation, permanent HBP was associated with reduction in death or HFH during long-term follow-up compared to RVP, and wasassociated with higher rates of lead revisions and generator change.
200 citations
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TL;DR: Long-term clinical results after FIRM ablation in this cohort of patients showed poor efficacy, different from previously published studies.
194 citations
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TL;DR: Permanent cardiac pacing of the His-bundle restores and retains normal electrical activation of the ventricles and improves left ventricular ejection fractions during follow-up.
Abstract: Aims Permanent cardiac pacing of the His-bundle restores and retains normal electrical activation of the ventricles. Data on His-bundle pacing (HBP) are largely limited to small single-centre reports, and clinical benefits and risks have not been systematically examined. We sought to systematically examine published studies of patients undergoing permanent HBP and quantify the benefits and risks of the therapy. Methods and results PubMed, Embase, and Cochrane Library were searched for full-text articles on permanent HBP. Clinical outcomes of interest included implant success rate, procedural and lead complications, pacing thresholds, QRS duration, and ejection fraction at follow-up, and mortality. Data were extracted and summarized. Where possible, meta-analysis of aggregate data was performed. Out of 2876 articles, 26 met the inclusion criteria representing 1438 patients with an implant attempt. Average age of patients was 73 years and 62.1% were implanted due to atrioventricular block. Overall average implant success rate was 84.8% and was higher with use of catheter-delivered systems (92.1%; P 3 months follow-up; although, pulse widths varied at testing. Average left ventricular ejection fractions (LVEFs) were 42.8% at baseline and 49.5% at follow-up. There were 43 complications observed in 907 patients across the 17 studies that reported safety information. Conclusion Among 26 articles of permanent HBP, the implant success rate averaged 84.8% and LVEF improved by an average of 5.9% during follow-up. Specific reporting of our clinical outcomes of interest varied widely, highlighting the need for uniform reporting in future HBP trials.
173 citations
Cited by
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TL;DR: The Task Force for the management of atrial fibrillation of the European Society of Cardiology has been endorsed by the European Stroke Organisation (ESO).
Abstract: The Task Force for the management of atrial fibrillation of the European Society of Cardiology (ESC)
Developed with the special contribution of the European Heart Rhythm Association (EHRA) of the ESC
Endorsed by the European Stroke Organisation (ESO)
5,255 citations
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4,960 citations
01 Jan 2017
3,603 citations
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TL;DR: The next chair and vice-chair will be announced at a special meeting of the American Academy of Anti-Accident and Accident Medicine (AACC) board of directors in New York on Wednesday, 2 March 2017.
1,707 citations
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TL;DR: Writing Group Members* Craig T. January,MD, PhD, FACC (Chair), L. Samuel Wann, MD, MACC, FAHA (Vice Chair), Hugh Calkins, MD , FACC, FAha, FHRS,* Lin Y. Chen, MD*, Joaquin E. Cigarroa, MD., MD, F ACC, Joseph C. Cleveland Jr.
Abstract: Writing Group Members* Craig T. January, MD, PhD, FACC (Chair), L. Samuel Wann, MD, MACC, FAHA (Vice Chair), Hugh Calkins, MD, FACC, FAHA, FHRS,* Lin Y. Chen, MD, MS, FACC, FAHA, FHRS, Joaquin E. Cigarroa, MD, FACC, Joseph C. Cleveland Jr., MD, FACC,*,x Patrick T. Ellinor, MD, PhD,* Michael D. Ezekowitz, MBChB, DPhil, FACC, FAHA,*,k Michael E. Field, MD, FACC, FAHA, FHRS,k Karen L. Furie, MD, MPH, FAHA,k Paul A. Heidenreich, MD, FACC, FAHA,{ Katherine T. Murray, MD, FACC, FAHA, FHRS,k Julie B. Shea, MS, RNCS, FHRS,*,k Cynthia M. Tracy, MD, FAHA,k Clyde W. Yancy, MD, MACC, FAHAk
1,691 citations