scispace - formally typeset
Search or ask a question
Author

Parma Nand

Bio: Parma Nand is an academic researcher from Sharda University. The author has contributed to research in topics: Routing protocol & Linked data. The author has an hindex of 13, co-authored 108 publications receiving 705 citations. Previous affiliations of Parma Nand include Indian Institute of Technology Roorkee & Auckland University of Technology.


Papers
More filters
Journal ArticleDOI
TL;DR: Anticoagulation for OPCAB surgery with bivalirudin was feasible without a clinically important increase in perioperative blood loss; the impact of this on clinical outcomes requires a larger study.

104 citations

Journal ArticleDOI
TL;DR: Since any impairment in the pathways associated with NF‐κβ signaling causes altered neuronal dynamics, neurotherapeutics using compounds including, antioxidants, bioflavonoids, and non‐steroidal anti‐inflammatory drugs against such abnormalities offer possibilities to rectify aberrant excitatory neuronal activity in AD.
Abstract: Alzheimer's disease (AD) is a typical progressive, chronic neurodegenerative disorder with worldwide prevalence. Its clinical manifestation involves the presence of extracellular plaques and intracellular neurofibrillary tangles (NFTs). NFTs occur in brain tissues as a result of both Aβ agglomeration and Tau phosphorylation. Although there is no known cure for AD, research into possible cures and treatment options continues using cell-cultures and model animals/organisms. The nuclear factor-kappa β (NF-κβ) plays an active role in the progression of AD. Impairment to this signaling module triggers undesirable phenotypic changes such as neuroinflammation, activation of microglia, oxidative stress related complications, and apoptotic cell death. These imbalances further lead to homeostatic abnormalities in the brain or in initial stages of AD essentially pushing normal neurons toward the degeneration process. Interestingly, the role of NF-κβ signaling associated receptor-interacting protein kinase is currently observed in apoptotic and necrotic cell death, and has been reported in brains. Conversely, the NF-κβ signaling pathway has also been reported to be involved in normal brain functioning. This pathway plays a crucial role in maintaining synaptic plasticity and balancing between learning and memory. Since any impairment in the pathways associated with NF-κβ signaling causes altered neuronal dynamics, neurotherapeutics using compounds including, antioxidants, bioflavonoids, and non-steroidal anti-inflammatory drugs against such abnormalities offer possibilities to rectify aberrant excitatory neuronal activity in AD. In this review, we have provided an extensive overview of the crucial role of NF-κβ signaling in normal brain homeostasis. We have also thoroughly outlined several established pathomechanisms associated with NF-κβ pathways in AD, along with their respective therapeutic approaches.

85 citations

Journal ArticleDOI
TL;DR: The paper explores NLG architectures and tasks classed under document planning, micro-planning and surface realization modules and identifies the gaps existing in the NLG research which require further work in order to make NLG a widely usable technology.
Abstract: Natural Language Generation (NLG) is defined as the systematic approach for producing human understandable natural language text based on non-textual data or from meaning representations. This is a significant area which empowers human-computer interaction. It has also given rise to a variety of theoretical as well as empirical approaches. This paper intends to provide a detailed overview and a classification of the state-of-the-art approaches in Natural Language Generation. The paper explores NLG architectures and tasks classed under document planning, micro-planning and surface realization modules. Additionally, this paper also identifies the gaps existing in the NLG research which require further work in order to make NLG a widely usable technology.

48 citations

Journal ArticleDOI
22 Nov 2019-Genes
TL;DR: Recent progress in breast cancer research has provided new perceptions into the molecular mechanisms behind Notch-mediated EMT regulation during breast tumorigenesis, which is a key process for large-scale cell movement at the time of embryonic development.
Abstract: Notch signaling is a primitive signaling pathway having various roles in the normal origin and development of each multicellular organisms. Therefore, any aberration in the pathway will inevitably lead to deadly outcomes such as cancer. It has now been more than two decades since Notch was acknowledged as an oncogene in mouse mammary tumor virus-infected mice. Since that discovery, activated Notch signaling and consequent up-regulation of tumor-promoting Notch target genes have been observed in human breast cancer. Moreover, consistent over-expression of Notch ligands and receptors has been shown to correlate with poor prognosis in human breast cancer. Notch regulates a number of key processes during breast carcinogenesis, of which, one key phenomenon is epithelial–mesenchymal transition (EMT). EMT is a key process for large-scale cell movement during morphogenesis at the time of embryonic development. Cancer cells aided by transcription factors usurp this developmental program to execute the multi-step process of tumorigenesis and metastasis. In this review, we recapitulate recent progress in breast cancer research that has provided new perceptions into the molecular mechanisms behind Notch-mediated EMT regulation during breast tumorigenesis.

47 citations

Journal ArticleDOI
TL;DR: The use of rapid ventricular pacing during 15 aortic stenting procedures has advantages over pharmacologic or other methods of blood pressure reduction.

35 citations


Cited by
More filters
01 Jun 2005

3,154 citations

01 Jan 2016
TL;DR: The handbook of psychological testing is universally compatible with any devices to read and is available in the digital library an online access to it is set as public so you can download it instantly.
Abstract: Thank you very much for reading handbook of psychological testing. As you may know, people have search hundreds times for their favorite readings like this handbook of psychological testing, but end up in infectious downloads. Rather than reading a good book with a cup of tea in the afternoon, instead they juggled with some infectious virus inside their laptop. handbook of psychological testing is available in our digital library an online access to it is set as public so you can download it instantly. Our digital library hosts in multiple countries, allowing you to get the most less latency time to download any of our books like this one. Kindly say, the handbook of psychological testing is universally compatible with any devices to read.

1,177 citations

Journal ArticleDOI
01 Feb 2012-Chest
TL;DR: This article suggests that platelet count monitoring should be performed every 2 or 3 days for patients receiving heparin in whom clinicians consider the risk of HIT to be > 1%, and suggests the use of argatroban or lepirudin or danaparoid over other nonheparin anticoagulants.

880 citations

Journal ArticleDOI
01 Sep 2004-Chest
TL;DR: This chapter about the recognition, treatment, and prevention of heparin-induced thrombocytopenia (HIT) is part of the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy: Evidence Based Guidelines.

825 citations