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Partha Roy

Bio: Partha Roy is an academic researcher from Adamas University. The author has contributed to research in topics: Andrographolide & Colloidal gold. The author has an hindex of 12, co-authored 23 publications receiving 505 citations. Previous affiliations of Partha Roy include Universiti Malaysia Pahang & University of Calcutta.

Papers
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Journal ArticleDOI
TL;DR: New quercetin conjugated gold nanoparticles (QAunp) were successfully evaluated for the first time against leishmanial macrophage infections.

104 citations

Journal ArticleDOI
TL;DR: Antileishmanial activity was found to be significant for the nanoparticle preparation with 4% PVA in about one-fourth of the dosage of the pure compound AG (IC50 160 μM), which have significant potential to target the infested macrophage cells and prove valuable in chemotherapy of neglected tropical diseases such as leishmaniasis.
Abstract: Andrographolide (AG) is a diterpenoid lactone isolated from the leaves of Andrographis paniculata. AG is a potent and low-toxicity antileishmanial agent. Chemotherapy applications of AG are, however, seriously constrained because of poor bioavailability, short plasma half-life, and inappropriate tissue localization. Nanoparticulation of AG was therefore envisaged as a possible solution. AG nanoparticles (AGnp) loaded in 50:50 poly(DL-lactide-co-glycolic acid) were prepared for delivery into the monocyte-macrophage cells infested with the amastigote form of leishmanial parasite for evaluation in the chemotherapy of leishmaniasis. Particle characteristics of AGnp were optimized by proportionate application of a stabilizer, polyvinyl alcohol (PVA). Physicochemical characterization of AGnp by photon correlation spectroscopy exhibited an average particle size of 173 nm and zeta potential of -34.8 mV. Atomic force microscopy visualization revealed spherical nanoparticles with a smooth surface. Antileishmanial activity was found to be significant for the nanoparticle preparation with 4% PVA (IC₅₀) 34 μM) in about one-fourth of the dosage of the pure compound AG (IC₅₀) 160 μM). AGnp therefore have significant potential to target the infested macrophage cells and prove valuable in chemotherapy of neglected tropical diseases such as leishmaniasis.

78 citations

Journal ArticleDOI
TL;DR: Silymarin nanoparticles (Smnps) were strongly protective against hepatic damage when tested in a paracetamol overdose hepatotoxicity model and recorded no animal death even when administered after an established par acetamol-induced hepatic necrosis.
Abstract: Silymarin (Sm) is a polyphenolic component extracted from Silybum marianum It is an antioxidant, traditionally used as an immunostimulant, hepatoprotectant, and dietary supplement Relatively recently, Sm has proved to be a valuable chemopreventive and a useful antineoplastic agent Medical success for Sm is, however, constrained by very low aqueous solubility and associated biopharmaceutical limitations Sm flavonolignans are also susceptible to ion-catalyzed degradation in the gut Proven antihepatotoxic activity of Sm cannot therefore be fully exploited in acute chemical poisoning conditions like that in paracetamol overdose Moreover, a synchronous delivery that is required for hepatic regeneration is difficult to achieve by itself This work is meant to circumvent the inherent limitations of Sm through the use of nanotechnology Sm nanoparticles (Smnps) were prepared by nanoprecipitation in polyvinyl alcohol stabilized Eudragit RS100(®) polymer (Rohm Pharma GmbH, Darmstadt, Germany) Process parameter optimization provided 6739% entrapment efficiency and a Gaussian particle distribution of average size 12037 nm Sm release from the nanoparticles was considerably sustained for all formulations Smnps were strongly protective against hepatic damage when tested in a paracetamol overdose hepatotoxicity model Nanoparticles recorded no animal death even when administered after an established paracetamol-induced hepatic necrosis Preventing progress of paracetamol hepatic damage was traced for an efficient glutathione regeneration to a level of 113 μmol/g in hepatic tissue due to Smnps

66 citations

Journal ArticleDOI
03 Jul 2014-PLOS ONE
TL;DR: New surface engineered biopolymeric nanoparticles with high silybin encapsulation efficiency and zeta potential were designed and evaluated in vivo for the first time in experimental diabetic conditions, recovering substantially and animal health recovered substantially.
Abstract: Silybin, is one imminent therapeutic for drug induced hepatotoxicity, human prostrate adenocarcinoma and other degenerative organ diseases. Recent evidences suggest that silybin influences gluconeogenesis pathways favorably and is beneficial in the treatment of type 1 and type 2 diabetes. The compound however is constrained due to solubility (0.4 mg/mL) and bioavailabilty limitations. Appropriate nanoparticle design for silybin in biocompatible polymers was thus proposed as a probable solution for therapeutic inadequacy. New surface engineered biopolymeric nanoparticles with high silybin encapsulation efficiency of 92.11% and zeta potential of +21 mV were designed. Both the pure compound and the nanoparticles were evaluated in vivo for the first time in experimental diabetic conditions. Animal health recovered substantially and the blood glucose levels came down to near normal values after 28 days treatment schedule with the engineered nanoparticles. Restoration from hyperglycemic damage condition was traced to serum insulin regeneration. Serum insulin recovered from the streptozotocin induced pancreatic damage levels of 0.17±0.01 µg/lit to 0.57±0.11 µg/lit after nanoparticle treatment. Significant reduction in glycated hemoglobin level, and restoration of liver glycogen content were some of the other interesting observations. Engineered silybin nanoparticle assisted recovery in diabetic conditions was reasoned due to improved silybin dissolution, passive transport in nanoscale, and restoration of antioxidant status.

54 citations

Journal ArticleDOI
TL;DR: The nanobiomaterial was observed to promote wound closure by inducing proliferation and migration of the keratinocytes at the wound site by exerting positive effects because of their antimicrobial properties.
Abstract: Wound healing is an innate physiological response that helps restore cellular and anatomic continuity of a tissue. Selective biodegradable and biocompatible polymer materials have provided useful scaffolds for wound healing and assisted cellular messaging. In the present study, guar gum, a polymeric galactomannan, was intrinsically modified to a new cationic biopolymer guar gum alkylamine (GGAA) for wound healing applications. Biologically synthesized silver nanoparticles (Agnp) were further impregnated in GGAA for extended evaluations in punch wound models in rodents. SEM studies showed silver nanoparticles well dispersed in the new guar matrix with a particle size of ~18 nm. In wound healing experiments, faster healing and improved cosmetic appearance were observed in the new nanobiomaterial treated group compared to commercially available silver alginate cream. The total protein, DNA, and hydroxyproline contents of the wound tissues were also significantly higher in the treated group as compared with the silver alginate cream (). Silver nanoparticles exerted positive effects because of their antimicrobial properties. The nanobiomaterial was observed to promote wound closure by inducing proliferation and migration of the keratinocytes at the wound site. The derivatized guar gum matrix additionally provided a hydrated surface necessary for cell proliferation.

51 citations


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Journal ArticleDOI
TL;DR: In this article, a review has focused on the various plant-mediated nanoparticle fabrication approaches, with brief discussions on the categories of various plant mediated synthesis approaches and mechanistic aspects of plant mediated nanoparticle synthesis.
Abstract: In recent years, the progress of efficient green chemistry approaches for the fabrication of commercially viable noble metallic nanoparticles has become a major focus of researchers. The present review has focused on the various plant-mediated nanoparticle fabrication approaches, with brief discussions on the categories of various plant-mediated synthesis approaches and mechanistic aspects of plant-mediated nanoparticle synthesis. The review also focused on the commercial applications of plant-mediated noble metal nanoparticles. Significant remarks on the limitations of plant-mediated fabrication approaches with prospective future direction are also examined.

298 citations

Journal ArticleDOI
TL;DR: The aim of this review is to examine scientific studies concerning the effects derived from silymarin/silybin use in chronic liver diseases, cirrhosis and hepatocellular carcinoma.
Abstract: Silymarin is the extract of Silybum marianum, or milk thistle, and its major active compound is silybin, which has a remarkable biological effect. It is used in different liver disorders, particularly chronic liver diseases, cirrhosis and hepatocellular carcinoma, because of its antioxidant, anti-inflammatory and antifibrotic power. Indeed, the anti-oxidant and anti-inflammatory effect of silymarin is oriented towards the reduction of virus-related liver damages through inflammatory cascade softening and immune system modulation. It also has a direct antiviral effect associated with its intravenous administration in hepatitis C virus infection. With respect to alcohol abuse, silymarin is able to increase cellular vitality and to reduce both lipid peroxidation and cellular necrosis. Furthermore, silymarin/silybin use has important biological effects in non-alcoholic fatty liver disease. These substances antagonize the progression of non-alcoholic fatty liver disease, by intervening in various therapeutic targets: oxidative stress, insulin resistance, liver fat accumulation and mitochondrial dysfunction. Silymarin is also used in liver cirrhosis and hepatocellular carcinoma that represent common end stages of different hepatopathies by modulating different molecular patterns. Therefore, the aim of this review is to examine scientific studies concerning the effects derived from silymarin/silybin use in chronic liver diseases, cirrhosis and hepatocellular carcinoma.

270 citations

Journal ArticleDOI
14 May 2020
TL;DR: The present review aims to provide a brief overview of the therapeutic effects, new insights, and upcoming perspectives of Que.
Abstract: Quercetin (Que) and its derivatives are naturally occurring phytochemicals with promising bioactive effects. The antidiabetic, anti-inflammatory, antioxidant, antimicrobial, anti-Alzheimer's, antiarthritic, cardiovascular, and wound-healing effects of Que have been extensively investigated, as well as its anticancer activity against different cancer cell lines has been recently reported. Que and its derivatives are found predominantly in the Western diet, and people might benefit from their protective effect just by taking them via diets or as a food supplement. Bioavailability-related drug-delivery systems of Que have also been markedly exploited, and Que nanoparticles appear as a promising platform to enhance their bioavailability. The present review aims to provide a brief overview of the therapeutic effects, new insights, and upcoming perspectives of Que.

249 citations

Journal ArticleDOI
Daode Hu1, Changchun Lin1, Liang Liu1, Sining Li1, Yaping Zhao1 
TL;DR: In this paper, a solution enhanced dispersion by supercritical fluids (SEDS) was applied for the production of lutein/zein nanoparticles and the effects of the process variables on the morphology, drug loading, entrapment efficiency, and mean particle size of the nanoparticles were investigated.

165 citations