Author
Parvesh Singh
Other affiliations: Guru Nanak Dev University, Durban University of Technology
Bio: Parvesh Singh is an academic researcher from University of KwaZulu-Natal. The author has contributed to research in topics: Chemistry & Docking (molecular). The author has an hindex of 18, co-authored 130 publications receiving 1937 citations. Previous affiliations of Parvesh Singh include Guru Nanak Dev University & Durban University of Technology.
Topics: Chemistry, Docking (molecular), Lactam, Isatin, Cycloaddition
Papers published on a yearly basis
Papers
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TL;DR: This review article focuses on the recent developments (2010-2014) on various pharmacological and medicinal aspects of chalcones and their analogues.
521 citations
TL;DR: This review offers a medium on which future drug design and development toward diabetes management may be modelled (i.e. optimization via structural derivatization), as many of the drug candidates highlighted show promise as an effective anti-diabetic chemotherapy.
200 citations
TL;DR: An emphasis on the recent developments (2015-16) in anticancer hybrids with insights into their structure-activity relationship (SAR) and mechanism of action is provided.
173 citations
TL;DR: In this article, a critical review and a wide range of applications of Dithiocarba- mates (DTCs) in environmental samples are provided. But the characteristics of DTCs are reviewed with particular emphasis on inorganic speciation studies using state-of-the-art analytical instrumentation coupled with computational methods of analysis.
136 citations
TL;DR: Compound 8h, with an optimum alkyl chain length and a chloro substituent at the C-5 position of the isatin ring, displayed the best activity among the test compounds, with IC50 value of 1.21 μM against cultured W2-strain Plasmodium falciparum.
106 citations
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Journal Article•
28,685 citations
TL;DR: This review aims to highlight the recent evidence of chalcone as a privileged scaffold in medicinal chemistry and is expected to be a comprehensive, authoritative, and critical review of the chal cone template to the chemistry community.
Abstract: Privileged structures have been widely used as an effective template in medicinal chemistry for drug discovery. Chalcone is a common simple scaffold found in many naturally occurring compounds. Many chalcone derivatives have also been prepared due to their convenient synthesis. These natural products and synthetic compounds have shown numerous interesting biological activities with clinical potentials against various diseases. This review aims to highlight the recent evidence of chalcone as a privileged scaffold in medicinal chemistry. Multiple aspects of chalcone will be summarized herein, including the isolation of novel chalcone derivatives, the development of new synthetic methodologies, the evaluation of their biological properties, and the exploration of the mechanisms of action as well as target identification. This review is expected to be a comprehensive, authoritative, and critical review of the chalcone template to the chemistry community.
800 citations
TL;DR: This review highlights the trends in the use of nitrogen-based moieties in drug design and the development of different potent and competent candidates against various diseases.
Abstract: The analogs of nitrogen-based heterocycles occupy an exclusive position as a valuable source of therapeutic agents in medicinal chemistry. More than 75% of drugs approved by the FDA and currently available in the market are nitrogen-containing heterocyclic moieties. In the forthcoming decade, a much greater share of new nitrogen-based pharmaceuticals is anticipated. Many new nitrogen-based heterocycles have been designed. The number of novel N-heterocyclic moieties with significant physiological properties and promising applications in medicinal chemistry is ever-growing. In this review, we consolidate the recent advances on novel nitrogen-containing heterocycles and their distinct biological activities, reported over the past one year (2019 to early 2020). This review highlights the trends in the use of nitrogen-based moieties in drug design and the development of different potent and competent candidates against various diseases.
587 citations
TL;DR: An overview of potentiometric sensors that are capable of detecting toxic heavy metal ions in environmental samples is presented and discussed and several limitations do exist in terms of selectivity, limits of detection, dynamic ranges, applicability to specific problems, and reversibility.
Abstract: An overview of potentiometric sensors that are capable of detecting toxic heavy metal ions in environmental samples is presented and discussed. Notwithstanding the tremendous work performed so far,...
533 citations
TL;DR: Advances in lead compounds of 1,2,3-triazole-containing hybrids, conjugates, and their related heterocycles in medicinal chemistry published in 2018 are summarized.
398 citations