P
Parviz Ahmad-Nejad
Researcher at Witten/Herdecke University
Publications - 32
Citations - 3608
Parviz Ahmad-Nejad is an academic researcher from Witten/Herdecke University. The author has contributed to research in topics: Medical laboratory & External quality assessment. The author has an hindex of 12, co-authored 29 publications receiving 3458 citations. Previous affiliations of Parviz Ahmad-Nejad include Technische Universität München.
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Journal ArticleDOI
HSP70 as Endogenous Stimulus of the Toll/Interleukin-1 Receptor Signal Pathway
Ramunas M. Vabulas,Parviz Ahmad-Nejad,Sanghamitra Ghose,Carsten J. Kirschning,Rolf D. Issels,Hermann Wagner +5 more
TL;DR: It is found that TLR2 and TLR4 confer responsiveness to HSP70 in 293T fibroblasts and the expanding list of endogenous ligands able to activate the ancient Toll/IL-1 receptor signal pathway is in line with the “danger hypothesis” proposing that the innate immune system senses danger signals even if they originate from self.
Journal ArticleDOI
Endocytosed HSP60s Use Toll-like Receptor 2 (TLR2) and TLR4 to Activate the Toll/Interleukin-1 Receptor Signaling Pathway in Innate Immune Cells
Ramunas M. Vabulas,Parviz Ahmad-Nejad,Clarissa Prazeres da Costa,Thomas Miethke,Carsten J. Kirschning,Hans Häcker,Hermann Wagner +6 more
TL;DR: To understand the proinflammatory nature of HSP, signaling induced by human and chlamydial HSP60 is analyzed and revealed that adjuvanticity of H SP60 operates similar to that of classical pathogen-derived ligands.
Journal ArticleDOI
Bacterial CpG-DNA and lipopolysaccharides activate Toll-like receptors at distinct cellular compartments.
TL;DR: The need to characterize individual TLR at the very beginning of signal initiation in order to understand their diverse biological functions is stressed.
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The Toll-like receptor 7 (TLR7)-specific stimulus loxoribine uncovers a strong relationship within the TLR7, 8 and 9 subfamily.
Florian Heil,Parviz Ahmad-Nejad,Hiroaki Hemmi,Hubertus Hochrein,Franziska Ampenberger,Tanja Gellert,Harald Dietrich,Grayson B. Lipford,Kiyoshi Takeda,Shizuo Akira,Hermann Wagner,Stefan Bauer +11 more
TL;DR: It is concluded that TLR7, 8 and 9 form a functional subgroup within the TLR family that recognizes pathogen‐associated molecular patterns in endosomal/lysosomal compartments.
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Compartmentalized production of CCL17 in vivo: strong inducibility in peripheral dendritic cells contrasts selective absence from the spleen.
Judith Alferink,Ivo Lieberam,Wolfgang Reindl,Andrea Behrens,Susanne Weiß,Norbert Hüser,Klaus Gerauer,Ralf Ross,Angelika B. Reske-Kunz,Parviz Ahmad-Nejad,Hermann Wagner,Irmgard Förster +11 more
TL;DR: It is shown that CCL17 expression in mice is found in activated Langerhans cells and mature DCs located in various lymphoid and nonlymphoid organs, and is up-regulated after stimulation with Toll-like receptor ligands, indicating that CCR17 production is a hallmark of local DC stimulation in peripheral organs but is absent from the spleen as a filter of blood-borne antigens.