P
Pascal Schneider
Researcher at University of Lausanne
Publications - 332
Citations - 41307
Pascal Schneider is an academic researcher from University of Lausanne. The author has contributed to research in topics: B-cell activating factor & Receptor. The author has an hindex of 86, co-authored 318 publications receiving 38752 citations. Previous affiliations of Pascal Schneider include Biogen Idec & Oregon Health & Science University.
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Journal ArticleDOI
Inhibition of death receptor signals by cellular FLIP
Martin Irmler,Margot Thome,Michael Hahne,Pascal Schneider,Kay Hofmann,Véronique Steiner,Jean-Luc Bodmer,Michael Schröter,Kim Burns,Chantal Mattmann,Donata Rimoldi,Lars E. French,Jürg Tschopp +12 more
TL;DR: The characterization of an inhibitor of apoptosis is reported, designated FLIP (for FLICE-inhibitory protein), which is predominantly expressed in muscle and lymphoid tissues and may be implicated in tissue homeostasis as an important regulator of apoptotic regulation.
Journal ArticleDOI
Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule.
Nils Holler,Rossana Zaru,Olivier Micheau,Margot Thome,Antoine Attinger,Salvatore Valitutti,Jean-Luc Bodmer,Pascal Schneider,Brian Seed,Jürg Tschopp +9 more
TL;DR: F Fas kills activated primary T cells efficiently in the absence of active caspases, which results in necrotic morphological changes and late mitochondrial damage but no cytochrome c release.
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Mice transgenic for BAFF develop lymphocytic disorders along with autoimmune manifestations.
Fabienne Mackay,Stephen A. Woodcock,Pornsri Lawton,Christine Ambrose,Manfred Baetscher,Pascal Schneider,Jürg Tschopp,Jeffrey L. Browning +7 more
TL;DR: Mice transgenic for BAFF have vastly increased numbers of mature B and effector T cells, and develop autoimmune-like manifestations such as the presence of high levels of rheumatoid factors, circulating immune complexes, anti–DNA autoantibodies, and immunoglobulin deposition in the kidneys.
Journal ArticleDOI
BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth.
Pascal Schneider,Fabienne Mackay,Véronique Steiner,Kay Hofmann,Jean Luc Bodmer,Nils Holler,Christine Ambrose,Pornsri Lawton,Sarah A. Bixler,Hans Acha-Orbea,Danila Valmori,Pedro Romero,Christiane Werner-Favre,Rudolph H. Zubler,Jeffrey L. Browning,Jürg Tschopp +15 more
TL;DR: A novel member of the T NF family, designated BAFF (for B cell activating factor belonging to the TNF family), which is expressed by T cells and dendritic cells is described, suggesting that BAFF plays an important role as costimulator of B cell proliferation and function.
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Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors
Margot Thome,Pascal Schneider,Kay Hofmann,Helmut Fickenscher,Edgar Meinl,Frank Neipel,Chantal Mattmann,Kim Burns,Jean Luc Bodmer,Michael Schröter,Carsten Scaffidi,Peter H. Krammer,Marcus E. Peter,Jürg Tschopp +13 more
TL;DR: A new family of viral inhibitors (v-FLIPs) which interfere with apoptosis signalled through death receptors3 and which are present in several γ-herpesviruses (including Kaposi's-sarcoma-associated human herpesvirus-8), as well as in the tumorigenic human molluscipoxvirus4.