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Patrice Watson
Researcher at Creighton University
Publications - 154
Citations - 23013
Patrice Watson is an academic researcher from Creighton University. The author has contributed to research in topics: Cancer & Colorectal cancer. The author has an hindex of 65, co-authored 153 publications receiving 22404 citations. Previous affiliations of Patrice Watson include University of Southern California & University of Utah.
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Journal ArticleDOI
New clinical criteria for hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome) proposed by the International Collaborative group on HNPCC.
TL;DR: The establishment of a set of selection criteria for families with hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome) to provide a basis for uniformity in collaborative studies and a definition of HNPCC was proposed that was aimed at helping clinicians to identify families.
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Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer
Fredrick S. Leach,Nicholas C. Nicolaides,Nickolas Papadopoulos,Bo Liu,Jin Jen,Ramon Parsons,Päivi Peltomäki,Pertti Sistonen,Lauri A. Aaltonen,Minna Nyström-Lahti,Xin Yuan Guan,Ji Zhang,Paul S. Meltzer,Jing Wei Yu,Fa Ten Kao,David J. Chen,Karen M. Cerosaletti,R. E. Keith Fournier,Sean Todd,Tracey B. Lewis,Robin J. Leach,Susan L. Naylor,Jean Weissenbach,Jukka-Pekka Mecklin,Heikki Järvinen,Gloria M. Petersen,Stanley R. Hamilton,Jane Green,Jeremy R. Jass,Patrice Watson,Henry T. Lynch,Jeffrey M. Trent,Albert de la Chapelle,Kenneth W. Kinzler,Bert Vogelstein +34 more
TL;DR: Somatic as well as germline mutations of the gene were identified in RER+ tumor cells, and this mutS homolog is likely to be responsible for HNPCC.
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Mutation of a mutL homolog in hereditary colon cancer
Nickolas Papadopoulos,Nicholas C. Nicolaides,Ying Fei Wei,Steven M. Ruben,Kenneth C. Carter,Craig A. Rosen,William A. Haseltine,Robert D. Fleischmann,Claire M. Fraser,Mark Raymond Adams,J. Craig Venter,Stanley R. Hamilton,Gloria M. Petersen,Patrice Watson,Henry T. Lynch,Päivi Peltomäki,Jukka-Pekka Mecklin,Albert de la Chapelle,Kenneth W. Kinzler,Bert Vogelstein +19 more
TL;DR: A search of a large database of expressed sequence tags derived from random complementary DNA clones revealed three additional human mismatch repair genes, all related to the bacterial mutL gene, demonstrating that this gene is responsible for HNPCC.
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Genetics, natural history, tumor spectrum, and pathology of hereditary nonpolyposis colorectal cancer: An updated review
Henry T. Lynch,Thomas C. Smyrk,Patrice Watson,Stephen J. Lanspa,Jane F. Lynch,Patrick M. Lynch,R.Jennifer Cavalieri,C. Richard Boland +7 more
TL;DR: Current knowledge is summarized, with emphasis on the manner in which this knowledge can be employed effectively for diagnosis and management of HNPCC.
Journal ArticleDOI
Analysis of mismatch repair genes in hereditary non–polyposis colorectal cancer patients
Bo Liu,Ramon Parsons,Nickolas Papadopoulos,Nicholas C. Nicolaides,Henry T. Lynch,Patrice Watson,Jeremy R. Jass,Malcolm G. Dunlop,Andrew H. Wyllie,Päivi Peltomäki,Albert de la Chapelle,Stanley R. Hamilton,Bert Vogelstein,Kenneth W. Kinzler +13 more
TL;DR: This study demonstrates that a combination of techniques can be used to genetically diagnose tumor susceptibility in the majority of HNPCC kindreds and lays the foundation for genetic testing of this relatively common disease.